Département de Chimie Moléculaire

Overcoming Reversibility: Borrowing Hydrogen Enables Enantioselective Intermolecular Oxa-Michael Addition to α,β-Unsaturated Aldehydes

Abstract Chiral 1,3-dioxygenated motifs are key scaffolds in bioactive natural products, yet their synthesis via intermolecular oxa-Michael addition to α,β-unsaturated aldehydes remains challenging notably due to the high reversibility of the oxygenated nucleophile addition. This...