Delta University for Science and Technology

CD38 Inhibition Enhances FXR Signaling in Male Rats With Diabetic Steatohepatitis Through SIRT1‐Dependent Suppression of NLRP3

ABSTRACT Diabetic steatohepatitis, now clinically framed within metabolic dysfunction‐associated steatohepatitis (MASH), features progressive disruption of hepatic microarchitecture alongside sterile inflammatory microdomains. Farnesoid X receptor (FXR) activity is restrained by...

Fasudil Protects Against Diclofenac-Induced Hepatorenal and Gastric Injury via Modulation of ROCK/TLR4/SIRT1 Signaling and Preservation of Tight Junctions

Background: Diclofenac is a widely consumed non-steroidal anti-inflammatory drug, yet its clinical utility is limited by severe hepatotoxicity, acute kidney injury, and gastric ulceration. While the RhoA/ROCK pathway is implicated in inflammation, its potential as a therapeutic t...

The Role of Accounting Information Quality in Attracting Foreign Investment

تهدف الدراسة إلى تحليل الغلاقة بين جودة المعلومات المحاسبية وقرارات المستثمرين الأجانب وإختبار ما إذا كانت البيانات والمعلومات المالية ذات الجودة العالية من حيث الموثوقية والشفافية تساهم في جذب الاستثمارات الخارجية. وتأتي أهمية البحث من اعتماد المستثمرين الأجانب على التقارير الما...