Delhi Pharmaceutical Science and Research University

Capsaicin and diclofenac coloaded nanoemulsion gel optimized by quality by design approach of for the treatment of rheumatoid arthritis

Aims Rheumatoid arthritis (RA) is a chronic inflammatory disorder associated with progressive joint damage and pain. The present study aimed to develop and optimize a capsaicin – diclofenac-loaded nanoemulgel incorporating clove and olive oil for enhanced topical delivery and the...

In silico investigation of novel isatin derivatives as potential multi-target anticancer agents targeting VEGFR-2, EGFR, and caspase-6

The isatin scaffold has emerged as a promising platform for the development of anticancer agents, as evidenced by several clinically relevant isatin-based compounds. In this study, 85 novel isatin derivatives were designed based on literature reports and evaluated using drug-like...