Dartmouth Institute for Health Policy and Clinical Practice

Design Thinking Improved Transitional Care Management and Primary Care Continuity in Rural America

BACKGROUND: Transitional care management (TCM) supports timely postdischarge follow-up and is associated with decreased emergency department visits and 30-day readmissions. However, delivering TCM in rural settings remains challenging, and staff frequently report frustration with...

Pilot Study of Cannabis Use Reduction and Associated Functional Outcomes.

AIMS: Interventions for cannabis use disorder often reduce the frequency and quantity of use, but rarely achieve sustained abstinence. It remains unclear whether reductions in use (rather than sustained abstinence) result in meaningful improvements in functioning. This study eval...

A phase II pilot trial of an indoleamine 2,3-dioxygenase-1 (IDO1) inhibitor (INCB024360) plus a multipeptide melanoma vaccine (MELITAC 12.1) in patients with advanced melanoma, with sequential evaluation of the tumor microenvironment

Indoleamine 2,3-dioxygenase-1 (IDO1) can mediate immune dysfunction by reducing tryptophan (Trp) and increasing kynurenine (Kyn). The CITN-04 clinical trial (NCT01961115) tested the safety and clinical activity of combination therapy with IDO1 inhibitor epacadostat (INCB024360) p...

Association between index adenomas and advanced neoplasia at third surveillance colonoscopy: Data from the New Hampshire Colonoscopy Registry

Background: Due to a lack of data, the USMTSF does not provide guidance for the 3 rd surveillance exam for adenomas detected on index colonoscopy. Our aim was to assess advanced outcome risk at 3 rd surveillance in patients with index adenomas. Methods: We included patients from...