Dartmouth–Hitchcock Medical Center

A Prospective Randomized Trial to Assess Early versus Delayed Weight Bearing Following Operatively Treated Ankle Fractures in the United States

OBJECTIVES: To determine the safety of early versus delayed weight bearing and effectiveness for improving return-to-work following ankle fracture repair. METHODS: Design : Prospective randomized study. Setting: 19 United States Trauma Centers Patient Selection Criteria: Adult pa...

Integrated differential transcript usage and transcript abundance analyses reveal isoform-level remodeling in clear cell renal cell carcinoma

Clear cell renal cell carcinoma (ccRCC) is characterized by transcriptional reprogramming driven by hypoxia signaling, metabolic rewiring, and immune modulation. While gene-level analyses have defined key features of ccRCC biology, they do not capture isoform-level variation aris...

Expired endoscopic devices remain sterile and functional: an international multicentre study challenging current shelf-life criteria

Background and study aims Expired medical devices represent an environmental and economic concern, yet their magnitude and true shelf life remain poorly defined. We aimed to quantify the volume and cost of expired endoscopic devices and evaluate their sterility and functionality...

Survival and Reoperation After Intralesional Procedures Versus Resection and Reconstruction for Renal Cell Carcinoma Bone Metastases

Background: The management of renal cell carcinoma (RCC) long-bone metastases often involves surgery with either resection and reconstruction (R&R) or intralesional (IL) procedures. Some literature suggests that R&R improves survival and reduces the risk of recurrence and reopera...

Travel Time and Treatment Choice in Pelvic Organ Prolapse.

IMPORTANCE: Demographic shifts within the United States have led to an increased proportion of older adults living in rural areas, which brings additional challenges to accessing urogynecologic care. As a rural tertiary care center, we sought to explore how travel time affects a...

Rehabilitative and Conditioning Exercises That Selectively Activate Individual Lower Extremity Muscles: A Systematic Review

CONTEXT: Resistance training - the process of progressively overloading muscle fibers - is fundamental to muscle hypertrophy. People may benefit from intentional exercise prescription targeting selective muscle activation. There is a lack of synthesized literature on exercises ta...

Equivalence of DNA-based cytometry to clinical flow cytometry and CBC for immune cell quantification in peripheral blood

Clinical flow cytometry, the current standard for immune cell typing and quantification, requires intact cell membranes, complex reagents, and substantial infrastructure, making it a costly, technically demanding process. In contrast, methylation cytometry only requires the measu...

Building early career pathways in AI and medicine: a six-year pilot evaluation of the EDIT AI program

Artificial intelligence (AI) is rapidly reshaping biomedical research and clinical medicine, including cancer diagnostics, therapeutics, and healthcare delivery. Maximizing its translational impact will require a workforce capable not only of applying AI tools but also of underst...

Stereotactic Body Radiotherapy vs Moderately Hypofractionated IMRT for Localized Intermediate-Risk Prostate Cancer

Importance The treatment of prostate cancer with radiotherapy is evolving. How quickly radiotherapy can be delivered, and the relative risks and benefits of such a treatment, is of significant public interest. Objective To determine whether stereotactic body radiotherapy (SBRT) w...

Cost-Effectiveness of Endovascular vs Open Surgery for Chronic Limb-Threatening Ischemia

Importance: Choosing between endovascular and open (bypass) surgical revascularization for chronic limb-threatening ischemia has major implications for clinical practice. Objective: To evaluate the cost-effectiveness of endovascular vs bypass surgical revascularization. Design, S...