Dartmouth Cancer Center

Integrated differential transcript usage and transcript abundance analyses reveal isoform-level remodeling in clear cell renal cell carcinoma

Clear cell renal cell carcinoma (ccRCC) is characterized by transcriptional reprogramming driven by hypoxia signaling, metabolic rewiring, and immune modulation. While gene-level analyses have defined key features of ccRCC biology, they do not capture isoform-level variation aris...

Equivalence of DNA-based cytometry to clinical flow cytometry and CBC for immune cell quantification in peripheral blood

Clinical flow cytometry, the current standard for immune cell typing and quantification, requires intact cell membranes, complex reagents, and substantial infrastructure, making it a costly, technically demanding process. In contrast, methylation cytometry only requires the measu...

Building early career pathways in AI and medicine: a six-year pilot evaluation of the EDIT AI program

Artificial intelligence (AI) is rapidly reshaping biomedical research and clinical medicine, including cancer diagnostics, therapeutics, and healthcare delivery. Maximizing its translational impact will require a workforce capable not only of applying AI tools but also of underst...