Daping Hospital

Network pharmacology and metabolomics analysis of ginsenosides in fibrinolysis balance after hip arthroplasty

Abstract Total hip arthroplasty (THA) is an effective treatment for end‑stage hip disease. However, postoperative fibrinolytic imbalance is common and increases the risks of bleeding and thrombosis. Ginsenosides, the main active constituents of Panax ginseng , exhibit multiple ph...

IgG depletion by FcRn blockade is associated with changes in amyloid pathology and neurodegeneration in APP/PS1 mice

Abstract Background Autoimmune disorders are associated with an increased risk of developing Alzheimer’s Disease (AD). Dysregulated autoantibodies have been suggested to contribute to exacerbated amyloid-beta (Aβ) accumulation. Based on the potential contribution of humoral immun...

Efficacy, Efficiency, and Safety of a Poly-L-lactic Acid Cuff Tube Assisting for Microvascular Anastomosis

BACKGROUND: Vascular anastomosis is a cornerstone of microsurgery. Anastomosis time and vessel patency significantly influence surgical success. The disadvantages of the traditional hand-sewn method requires a high technical threshold, prolonged surgical time, and an increased ri...

A nomogram for differentiating false-negative from true-negative diagnoses following non-diagnostic CT-guided lung biopsy

This study aimed to develop and validate a nomogram that integrates clinical data, radiological findings, and biopsy procedural characteristics to distinguish false-negative from true-negative diagnoses in patients with non-diagnostic results following CT-guided lung biopsy. This...

Gut microbiome enterotypes associate with distinct metabolomic landscapes and clinical outcomes in inflammatory bowel disease: a multi‑omics dissection

The gut microbiota contributes to inflammatory bowel disease (IBD), but patient‑to‑patient variation in microbial dysbiosis remains poorly characterised. The gut‑brain axis is implicated in the high rate of psychiatric comorbidities in IBD, though the microbial and metabolic medi...

Development and Validation of Daping Orthopedics Operative Risk Scoring System for Geriatric Hip Fracture ( DOORS ‐ GHF ) for Predicting Postoperative Outcomes in Geriatric Hip Fracture Patients: A Multicenter Retrospective Comparative Study

ABSTRACT Objective With China's accelerating population aging, geriatric hip fractures pose a growing clinical challenge. High comorbidity burden and diminished physiological reserve drive elevated postoperative complication and mortality risks in this population. However, most e...

Circulating Protein Biomarkers for Primary Cardiomyopathy: Evidence from Mendelian Randomization and Clinical Validation

BACKGROUND: Primary (non-ischemic) cardiomyopathy poses diagnostic challenges due to phenotypic heterogeneity and non-specific clinical presentation, and commonly used circulating biomarkers have limited disease specificity. The aim was to prioritize mechanism-informed plasma bio...

Multi-omics mapping of TIMP1-associated stromal–myeloid remodeling in autoimmune gastritis and gastric cancer

Abstract Background Autoimmune gastritis (AIG) is a chronic immune-mediated atrophic disease that can induce cancer-related epithelial remodeling, although its association with gastric adenocarcinoma depends on histological and clinical modifiers. Gastric cancer (GC) progression...

Association between serum lactate trajectories and short-term mortality in pediatric acute kidney injury patients

OBJECTIVE: Acute kidney injury (AKI) is a life-threatening condition in children. Serum lactate is a critical indicator of oxygen metabolism and tissue hypoperfusion. This study investigated the association between early dynamic lactate trajectories during pediatric intensive car...

Neural-specific UBAP2L deficiency causes developmental delay and cortical abnormalities in mice

Rare UBAP2L variants have been linked to neurodevelopmental disorders (NDDs), such as autism spectrum disorder (ASD), but the role of UBAP2L in brain development remains unclear. Here, we generated neural-specific conditional knockout mice for Ubap2l using Nestin-Cre system, incl...

Evaluative performance of triglyceride-glucose-frailty index versus surrogate insulin resistance indices for advanced cardiovascular-kidney-metabolic syndrome, cardiometabolic multimorbidity, and mortality: the role of estimated glomerular filtration rate

Cardiovascular-kidney-metabolic (CKM) syndrome and cardiometabolic multimorbidity (CMM) carry substantial mortality, yet whether a composite index integrating insulin resistance and frailty shows stronger associations with advanced CKM syndrome, CMM, and mortality than convention...

Ticagrelor-Aspirin With Thrombolysis by Infarct Patterns in Moderate Ischemic Stroke: TAPIS Subgroup Analysis

BACKGROUND: Whether diffusion‑weighted imaging infarction patterns influence the efficacy and safety of early oral ticagrelor‑aspirin with intravenous thrombolysis in moderate acute ischemic stroke is uncertain. We assessed treatment effects by infarction pattern in this thrombol...

Impaired amyloid-beta uptake and distinct transcriptomic profiles of monocytes in APOE4 carriers: The Chongqing Ageing and Dementia Study

The ε4 allele of the apolipoprotein E gene (APOE4) is the strongest genetic risk factor for sporadic Alzheimer’s disease (AD). However, its impact on monocyte-mediated amyloid-β (Aβ) clearance and associated immune dysfunction remains poorly understood. Through Aβ uptake assays i...

Longitudinal plasma phosphorylated tau217 classification and the association with Alzheimer's disease progression

Abstract INTRODUCTION Longitudinal diagnostic and prognostic validity of plasma phosphorylated tau217 (p‐tau217) in Alzheimer's disease (AD) remains uncertain. METHODS In this multi‐cohort study of 2117 individuals, we established baseline plasma p‐tau217 thresholds for amyloid‐β...

Candidate role of ADAMTS2 in regulating keratinocyte apoptosis via indirect NF-κB modulation in life-threatening PD-1 inhibitor-induced TEN-like cutaneous toxicity

Abstract Toxic epidermal necrolysis-like (TEN-like) immune-related cutaneous adverse event (ircAE) induced by programmed death 1 (PD-1) inhibitors is life-threatening; however, its pathogenesis remains unclear. This study aimed to dynamically characterize molecular signatures and...

Patient with repeated cerebral vascular occlusion receive three thrombolysis and two endovascular treatments within 103 hours: a case report

Restoring blood flow through intravenous thrombolysis (IVT) or endovascular treatment (EVT) is the most effective therapy for acute ischemic stroke (AIS). However, reocclusion remains a common complication in patients who achieve successful revascularization. Currently, there is...

Association between beta-blocker selectivity and mortality in left heart failure patients with comorbid COPD

To evaluate the Impact of posterior to intensive care unit (ICU) beta-blockers use with the clinical outcomes in patients with left heart failure(LHF) and chronic obstructive pulmonary disease(COPD). Patients with LHF and COPD were selected from the Medical Information Mart for I...

A Novel Preclinical Rat Model of Acute Compartment Syndrome

Acute compartment syndrome (ACS) is common in trauma, challenging early diagnosis and treatment. An accurate ACS model is vital for its management. Most prior animal models have induced intrafascial hypertension by exogenous interventions, focusing on the study of secondary injur...

SERPINC1-mediated hereditary antithrombin deficiency with refractory pulmonary embolism: successful treatment with VA-ECMO and interventional thrombus aspiration

Venous thromboembolism (VTE) carries substantial global morbidity and mortality, with 50%–60% of disease variability attributed to genetic factors. Hereditary antithrombin deficiency (HATD), caused by pathogenic variants in the SERPINC1 gene, is an autosomal dominant thrombophili...

Mitochondrial MAP4 regulates keratinocyte autophagy, apoptosis, and migration upon wounding through BCL2/SIRT5 functional coupling under hypoxia: an experimental in vitro study

Microtubule-associated protein 4 (MAP4) phosphorylates and translocates to the outer mitochondrial membrane, thus promoting keratinocyte migration under hypoxia; however, the underlying mechanism remains unclear. Given that a BCL2 homology 3-like (BH3-like) domain has been previo...