Daping Hospital

SERPINC1-mediated hereditary antithrombin deficiency with refractory pulmonary embolism: successful treatment with VA-ECMO and interventional thrombus aspiration

Venous thromboembolism (VTE) carries substantial global morbidity and mortality, with 50%–60% of disease variability attributed to genetic factors. Hereditary antithrombin deficiency (HATD), caused by pathogenic variants in the SERPINC1 gene, is an autosomal dominant thrombophili...

Mitochondrial MAP4 regulates keratinocyte autophagy, apoptosis, and migration upon wounding through BCL2/SIRT5 functional coupling under hypoxia: an experimental in vitro study

Microtubule-associated protein 4 (MAP4) phosphorylates and translocates to the outer mitochondrial membrane, thus promoting keratinocyte migration under hypoxia; however, the underlying mechanism remains unclear. Given that a BCL2 homology 3-like (BH3-like) domain has been previo...

Rapamycin‐nanoliposomes target the mTORC1 ‐mediated autophagy–lysosomal and NLRP3 /Caspase‐1 pathways to inhibit nucleus pulposus cell senescence in intervertebral discs

Abstract Nucleus pulposus (NP) cell quiescence maintains intervertebral disc homeostasis, while mTORC1 regulates autophagy–lysosomal function and inflammatory secretion to preserve quiescence—rapamycin specifically targets mTORC1. Herein, we fabricated rapamycin‐nanoliposomes (ra...