Danish Cancer Society

Risk of malignant melanoma in hyperthyroid and hypothyroid female populations: Results from a large Danish cohort study

Introduction Experimental studies suggest that thyroid hormones may influence tumor development through endocrine and cellular signaling pathways. Although malignant melanoma (MM) is primarily associated with ultraviolet radiation exposure, the potential role of thyroid dysfuncti...

Persistent Health Disparities Among Adult Cancer Survivors

ABSTRACT Cancer survivors face elevated risks of age‐ and treatment‐related health conditions, possibly due to accelerated biological aging from cancer therapy. The role of social determinants of health (SDOH) in these aging trajectories remains understudied. We conducted a retro...

Residential road traffic noise and incidence of depression in Denmark: a nationwide cohort study

Background Evidence linking transportation noise to depression is limited. We investigated associations between road traffic noise at the most (LdenMax) and least (LdenMin) exposed façades and depression risk in Denmark. Methods We established a nationwide cohort of 2,941,456 adu...

Use of Ibuprofen Before and in Early Pregnancy Among Women With and Without Chronic Medical Diseases. A Cross‐Sectional Study

PURPOSE: While having a chronic medical disease (CMD) increases use of analgesics and anti-inflammatory drugs, sufficient knowledge regarding patterns of use during pregnancy is lacking. We aimed to describe ibuprofen use before and in early pregnancy among women with and without...

Childhood body mass index trajectories and subtypes of endometrial cancer: A Danish cohort study

Background Obesity in adulthood is a well-established risk factor for endometrial cancer, a heterogeneous disease comprising several histological subtypes. Although childhood body mass index (BMI) is linked to endometrial cancer, the role of childhood growth patterns in different...

Household consumer purchases and chronic disease

Chronic disease risk stratification remains costly and often provides limited insight into modifiable exposures. Consumer purchases are routinely generated, low-burden measures of household lifestyle that can be linked to health outcomes with consent. In this Danish cohort study,...

Trends in early-onset cancer incidence rates in the Nordic countries (2003–2022): a population-based study

Background Increasing incidence rates of early-onset cancer at ages 20–49 years have been reported in several countries, especially for colorectal, kidney and breast cancer. We examined recent incidence trends of early-onset cancer in Denmark, Finland, Iceland, Norway, Sweden, Gr...

p16 Overexpression and Human Papillomavirus Positivity in More Than 1000 Penile Cancers

Penile cancer is a severe disease, and a large proportion is related to high-risk (hr) human papillomavirus (HPV). P16 is used as an immunohistochemical marker of HPV in clinical diagnostics. Population-based data on the prevalence of p16 in penile cancer is scarce. We investigat...

Copenhagen longitudinal study on quality of life in a young adult population with gliomas

Abstract Background Patients diagnosed with glioma in the brain are prone to lowered quality of life (QoL). The risk of neurological symptoms and emotional burden may restrict participation in everyday life.The glioma diagnosis is considered chronic with a limited overall surviva...

Truncated ErbB2 receptor expression lowers nucleus stiffness and increases migration of breast cancer cells

The mechanisms underlying mechanical differences among cancer cell lines with varying metastatic potential remain poorly understood, despite their clear therapeutic relevance. While comparisons between malignant and benign cell mechanics reveal systematic differences, these are d...

Occupational exposure to noise and depression incidence: a nationwide cohort study of workers in Denmark, 2000–2017

Objectives Research on the association between occupational noise and incident depression is limited. We investigated whether long-term occupational noise was associated with depression risk, both independently and in combination with other stress-related factors. Methods In a Da...

Risk Factors for Estrogen Receptor Subtype‐Specific Contralateral Breast Cancer in Women Under Age 55 Years

Women with estrogen receptor negative (ER-) contralateral breast cancer (CBC) are 50% more likely to die of CBC compared to women with estrogen receptor positive (ER+) CBC. We comprehensively investigated risk factors for ER subtype-specific CBC using the Women's Environmental Ca...