Dana-Farber/Harvard Cancer Center

Mixed-Method Analysis of a National Survey of Hospitals with Inpatient Hepatitis C Treatment Initiatives

Abstract We surveyed clinicians about efforts to initiate hepatitis C antivirals during hospitalization or at discharge. We identified 29 hospitals in the United States working on such initiatives, with most efforts being less than 3 years old. Further initiative expansion is hin...

Human-in-the-loop large language model framework for identification of cutaneous immune-related adverse events

This study evaluated a retrieval-augmented, multi-agent large language model (LLM)–driven, human-in-the-loop framework for detecting cutaneous immune-related adverse events (cirAEs) from clinical notes. Compared with the unassisted manual-review group, the LLM-assisted group demo...

Lung Function–Associated Genetic Variants and Overall Survival in Non–Small Cell Lung Cancer: A Multi-Platform Analysis

Abstract Background: Genome-wide association studies (GWAS) have identified numerous variants associated with spirometric lung function, and Mendelian randomization studies suggest that impaired pulmonary function contributes to lung cancer susceptibility. Whether these variants...

Pancreatic Reirradiation: A Multi-Institutional Retrospective Analysis of Feasibility, Tolerability, and Clinical Outcomes

Objectives: With improvements in systemic therapy for pancreatic cancer (PC), the role of radiation therapy (RT) to optimize local control has increased. While the tolerability and outcomes for RT for PC are well described, limited data exist on the feasibility and clinical impac...

Melanoma Prognostication Using AI ‐Guided Histopathology

Accurate diagnosis and risk stratification are central for optimal management of patients with melanoma. Current American Joint Committee on Cancer (AJCC) staging systems inadequately stratify patients with clinically meaningful metastatic potential. Manual histopathologic interp...

Between Bandung, Suez, and Nehru's Feet: Singapore and Global South Solidarities in the Commonwealth

As part of his voyage to London in December 1955, David Marshall, chief minister of the British colony of Singapore, toured the newly independent Commonwealth countries of Ceylon, India, and Pakistan. This article follows his movement across South Asia, foregrounding the dynamics...

Measuring the Carbon Footprint for Health Systems and Suppliers: A Collaborative Field Study by Providence and Becton Dickinson

The carbon emissions from assets owned by health systems are a small fraction of their total carbon footprint. The emissions produced by their suppliers of products and services - such as electricity and transportation - are typically more than 10 times a hospital's direct emissi...

ENSO-driven multi-decadal climate variability in Auckland: a Southern Hemisphere coastal city perspective

Coastal cities in Southern Hemisphere mid-latitudes face climate risks from interacting tropical and polar atmospheric systems. This study examines multi-decadal climate variability in Auckland (37°S), New Zealand’s largest city, using 1963–2022 records. Morlet wavelet analysis a...

Optimal Public Transportation Networks: Evidence from the World's Largest Bus Rapid Transit System in Jakarta

Designing public transport networks involves trade-offs between coverage, service frequency, and direct service. We use the expansion of the bus system in Jakarta, Indonesia, to study these trade-offs. We analyze how new direct connections, changes in bus travel time, and wait-ti...

The Reading Brain from Womb to Classroom: Typical and Atypical Development and Implications for a Preventative Education Model

Learning to read is a process and milestone with far-reaching implications for education, vocation, and health. Most models and empirical studies of reading development, however, focus on school entry and often limit potential influences to children's oral language and print-base...

Care Team Response to Patient Portal Message Content and Writing Style

Importance Patient portal messages are an increasingly central channel for patient-clinician communication, but there are inequities in how responsive care teams are to messages sent by patients from historically marginalized groups. The reasons driving these disparities are not...

Following the rules: which type 1 diabetes guidelines, protocols and recommendations are tertiary clinics in Australia following? A quantitative study

OBJECTIVES: This study characterises the use of type 1 diabetes (T1D) guidelines and protocols in Australian T1D clinics working with paediatric patients, and determines if management practices align with T1D-specific guidelines. METHODS: T1D clinic service leaders responded to a...