Damietta University

Psychological well-being among institutionalized older adults: The roles of mattering, alexithymia, and spirituality

BACKGROUND: Institutionalized older adults often face emotional challenges, including a diminished sense of mattering and difficulties in identifying or expressing emotions (alexithymia), both of which can negatively affect their psychological well-being. OBJECTIVES: The study ai...

Cooperative Modulation of the NF‐κB and p53 Pathways by Metronomic Cyclophosphamide and Metformin Inhibits Ehrlich Carcinoma Progression and Enhances Systemic Immunity

This study investigates the cooperative antitumor potential of combining metronomic cyclophosphamide (MTm-CTX) with the metabolic modifier metformin (MET) in a murine model of mammary carcinoma. While metronomic chemotherapy offers a reduced toxicity profile, its efficacy as a mo...

Dietary dose-dependent effects of Ginkgo biloba leaf extract on growth, immunity, antioxidant status, and hepatic integrity in Nile tilapia

Abstract The increasing demand for sustainable alternatives to in-feed antibiotics has stimulated interest in phytogenic feed additives. This study investigated the dose-dependent effects of dietary Ginkgo biloba leaf extract (GBLE: 0, 6, 12, 18, and 24 g/kg diet) in Nile tilapia...

DFT Investigations of Kubas-Type Hydrogen Storage in C₁₉X Heterofullerenes: d-Orbital Preservation Under Substitutional Transition Metal Doping

Hydrogen is a promising clean energy carrier, but safe and efficient solid-state storage remains a major challenge. Here, dispersion-corrected density functional theory (PBE-D3BJ/def2-TZVPD) was employed to investigate C₁₉X heterofullerenes (X = Si, Ge, Ti, V, Ni, and Zr) as hydr...

MUC5AC in pancreatic cancer and precursors: a systematic review and meta-analysis

Abstract Background Mucin5AC (MUC5AC) is a secretory glycoprotein that is highly expressed in pancreatic cancer and precursors. We assessed its diagnostic accuracy in differentiating pancreatic cancer and precursors from normal pancreas and benign pancreatic diseases. Methods Sys...

Silymarin and Zinc Oxide Nanoparticles Attenuate Experimental Colon Cancer in Rats Through Crosstalk of miR-192 and β-Catenin Pathways

Colon cancer (CC) is a leading cause of cancer-related mortality globally. Although chemotherapy remains the primary treatment, its toxicity and drug resistance highlight the need for alternative therapeutic strategies. Silymarin (Sily), a natural compound, and zinc oxide nanopar...

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face...

A Novel Strategy for Developing Engineered Cementitious Composites: Synergistic Incorporation of Volcanic Materials and PE-PVA Fibers

Engineered cementitious composites (ECC) are primarily designed to enhance ductility, achieving strain-hardening behavior and controlled micro-cracking. Key constituents typically include cement, fine aggregates, fly ash, and polymeric fibers. This study aims to replace conventio...

Empagliflozin mitigates lipopolysaccharide-induced tracheal injury in rats via downregulation of IL-6/JAK/STAT3 signaling pathway and stem cell preservation: histological and molecular study

Abstract Lipopolysaccharide (LPS) is a component of the Gram-negative bacterial cell wall and is considered a potent inflammatory inducer. Empagliflozin (EMPA) is a sodium-glucose co-transporter 2 inhibitor used in treatment of type 2 diabetes mellitus. Interleukin-6/Janus kinase...

Awareness level of cancer risk factors and warning signs among adults in Mansoura District, Egypt

BACKGROUND: Cancer remains a leading cause of mortality worldwide, with prevention and early detection dependent on the public awareness of its risk factors and warning signs. However, knowledge of cancer-related symptoms and modifiable risk factors remains limited in many popula...

Salinity stress and drought stress differentially affect biomass allocation, leaf orientation and performance of two sesame (Sesamum indicum L.) cultivars

<title>Abstract</title> Drought and salinity stresses are major threats to crop productivity in the arid lands. This work investigates the differential impact of salinity and drought on growth and performance of two sesame cultivars: Sohg and Shnd at water potentials of 0, -100,...

Early-Life Antibiotic Exposure Disrupts Bifidobacterium in Infants: A qPCR-Based Cohort Study

BACKGROUND: Early infancy represents a critical window for establishing the gut microbiome, during which Bifidobacterium species dominate and play essential roles in metabolic, immune and intestinal maturation. Antibiotic exposure during this sensitive period may disrupt microbia...

Chronic Ankle Instability and Low Back Pain: A Narrative Review With a Conceptual Framework Linking Distal and Proximal Sensorimotor Dysfunction

ABSTRACT Background Chronic ankle instability and chronic low back pain are highly prevalent in musculoskeletal conditions. Emerging evidence suggests that they are interconnected through shared biomechanical, neuromuscular, and neurophysiological mechanisms, where deficits in pr...

CD38 Inhibition Enhances FXR Signaling in Male Rats With Diabetic Steatohepatitis Through SIRT1‐Dependent Suppression of NLRP3

ABSTRACT Diabetic steatohepatitis, now clinically framed within metabolic dysfunction‐associated steatohepatitis (MASH), features progressive disruption of hepatic microarchitecture alongside sterile inflammatory microdomains. Farnesoid X receptor (FXR) activity is restrained by...

Vardenafil Alleviates Doxorubicin-Induced Cardiotoxicity Associated with Restoration of the AMPK/SIRT1 Signaling Pathway

Background: Doxorubicin-induced cardiotoxicity (DIC) is a major limitation of anthracycline chemotherapy and is characterized by oxidative stress, apoptosis, and myocardial remodeling. Dysregulation of AMP-activated protein kinase (AMPK) and its downstream effector sirtuin-1 (SIR...