Damascus Hospital

Expanding the clinical spectrum of DNASE1L3-associated monogenic lupus

Rationale: DNASE1L3 deficiency is a rare autosomal-recessive monogenic form of systemic lupus erythematosus, characterized by defective clearance of extracellular DNA, leading to immune-complex formation, autoantibody production, and systemic inflammation. While early-onset lupus...

Transient sinus bradycardia complicating acute severe ulcerative colitis a case report and review of the literature

Inflammatory bowel disease (IBD) is associated with extraintestinal cardiovascular effects. While tachycardia is common during active inflammation, bradycardia is exceptionally rare. We report a case of transient sinus bradycardia occurring during an acute severe ulcerative colit...