Daegu-Gyeongbuk Medical Innovation Foundation

Development and Preclinical Evaluation of Novel STK3/4 Inhibitors with Anti-Obesity Potential

Background: Obesity is associated with impaired adipocyte metabolism driven in part by mitochondrial dysfunction.Serine/ threonine-protein kinase 3 (STK3) and STK4 promote mitophagy, leading to reduced mitochondrial mass in adipose tissue.Thus, inhibition of STK3/4 represents a p...

Quantitative impact of tissue layer composition in transcranial focused ultrasound modeling

Transcranial focused ultrasound is widely used for treating brain diseases; however, skull-induced attenuation and aberration require numerical acoustic simulations for safe application. These simulations predominantly focus on skull modeling, whereas the soft tissues are often s...

Nine-Week Co-Supplementation with Sugarcane Wax Alcohol (Policosanol), Phosphatidylserine, and Ginkgo biloba Leaf Extract Attenuates the Metabolic Dysfunction and Oxidative Stress in Blood and Vital Organs of Hyperlipidemic/Hyperglycemic Zebrafish

Policosanol (sugarcane wax alcohol), phosphatidylserine, and Ginkgo biloba leaf extract are Ministry of Food and Drug Safety (MFDS), Republic of Korea-listed functional foods for health-promoting effects. Herein, a combination of policosanol, phosphatidylserine, and G. biloba lea...

( S )‐Pyrrolo[1,2‐ a ]pyrazine‐3‐carboxamide Analogs as Dual Akt/JNK Modulators With Antiproliferative Effects in MDA‐MB‐468 Cells

Triple‐negative breast cancer (TNBC) remains a major clinical challenge due to the absence of effective targeted therapies. In this study, thirty analogs of ( S )‐1‐oxo‐1,2,3,4‐tetrahydropyrrolo[1,2‐ a ]pyrazine‐3‐carboxamide ( A1 – F5 ) were designed, synthesized, and evaluated...