Czech Academy of Sciences, Institute of Inorganic Chemistry

Chemical Stabilizationand Transformation of SchiffBase Scaffold: A Path toward Superior Platinum-Based Anti-Cancer StemCell Drugs

Abstract The clinical application of platinum-based anticancer agents is limited by poor aqueous stability, low solubility, and dose-limiting toxicities. Here, we report two Pt(II) complexes based on a Schiff base ligand and its reduced imine derivative, designed to overcome thes...