Czech Academy of Sciences, Institute of Biotechnology

Galectin-3 restrains T cell-driven inflammation in the testis and epididymis

Abstract Galectin-3 (Gal-3) is a pleiotropic molecule involved in immune regulation and tissue homeostasis. While it has been implicated in reproductive tissue function, its role in shaping immune cell dynamics within the testis and epididymis remains incompletely defined. Here,...

Formulation and Physicochemical Stability Evaluation of a Polyherbal Cream Incorporating Turmeric, Neem, Green Tea, and Aloe Vera Extracts

Background: Skin aging is a multifactorial biological process driven by intrinsic factors such as genetic changes and hormonal decline, and extrinsic factors, primarily ultraviolet (UV) radiation, that trigger oxidative stress, chronic inflammation, collagen degradation by matrix...

Stem cell–derived islet replacement therapies for diabetes: current progress and translational challenges

Diabetes mellitus is a chronic metabolic disorder characterized by impaired glucose homeostasis resulting from insufficient insulin production, defective insulin action, or both. Despite major advances in pharmacological management, current treatments fail to fully restore physio...

Semi-automated strain engineering and screening in the thermophilic fungus Myceliophthora thermophila for recombinant protein production

ABSTRACT Thermophilic filamentous fungi are widely used for cellulase production at elevated temperatures; however, efficient recombinant protein production in these organisms remains limited because construction and screening of large transformant populations remain difficult. H...

Single‐Nucleus Transcriptome Analysis Provides New Insights Into B Chromosome Elimination in Sorghum

B chromosomes are supernumerary entities found in many plant species, with some exhibiting tissue-specific elimination. In Sorghum purpureosericeum, extensive B chromosome elimination occurs during embryogenesis affecting most of the embryonic organs, leaving the B chromosome mai...