Czech Academy of Sciences, Institute of Biophysics

Multiobjective Engineering of Fibrin-Selective Thrombolytic Proteases with Enhanced Biocatalytic Efficiency and Inhibition Resistance

Abstract Thrombolytic enzymes represent an important class of proteolytic biocatalysts for medical applications, yet currently used FDA-approved variants, including alteplase and tenecteplase, remain limited by suboptimal catalytic efficiency, off-target activity, and susceptibil...

Mercury in Fish from Guanabara Bay, Southeast Brazil: Tissue-Specific Accumulation and Human Health Risks

Abstract Guanabara Bay is Brazil’s second-largest bay and has a long history of intense industrial and domestic pollution. Some local communities rely on fish as a primary protein source, justifying an assessment of mercury (Hg) contamination. This study determined total mercury...

Chemical Synthesis of Acybolins Reveals Their Antiproliferative Activity

Abstract An efficient synthetic access to the acybolin class of inducible secondary metabolites is being reported. The approach developed features coupling between the antibiotic (−)-bactobolin A and various acybolin side chains without the need for protecting groups. The biologi...

Metal geochemistry in bottom sediments from an urbanized tropical estuary: implications for land disposal of dredged materials

Abstract The Fundão canal (RJ/Brazil) is an urbanized estuary impacted by eutrophication, metal contamination and silting, and was subjected to dredging operations to fulfill the demands of the 2016 Olympic Games. Given the scarcity of studies focused on the degradation of tropic...