Cyprus Institute of Neurology and Genetics

Mechanisms Linking Body Weight to Early Puberty in Children

Childhood overweight and obesity have been associated with earlier pubertal onset most commonly in girls than boys. This review aims to summarize proposed mechanisms involved in early puberty amongst children with increased weight and possibly help early detection and reduce any...

HAT1 regulates glioblastoma cell proliferation and membrane lipid remodeling through ALDH2

Abstract Glioblastoma (GBM) is the most aggressive and lethal form of primary brain cancer in adults, characterized by rapid cell proliferation, resistance to therapy, and poor patient outcomes. While epigenetic dysregulation is increasingly recognized in glioma pathogenesis, the...

Correlation of polygenic risk score and clinical phenotype in patients with genetic generalized epilepsy

Abstract Objective The polygenic risk score (PRS) for individuals with genetic generalized epilepsy (GGE) quantifies the common risk variants in genes identified in genome‐wide association studies. We hypothesized that the phenotype of GGE patients differs based on their GGE PRS....