CTO Hospital

Long-term results of the modified Dunn procedure in slipped capital femoral epiphysis

Aims: In situ fixation for slipped capital femoral epiphysis (SCFE) prevents further displacement, but fails to correct the proximal femoral deformity, which may lead to femoroacetabular impingement (FAI) and early osteoarthritis (OA). The modified Dunn procedure (MDP) restores p...

The Behavior of the External Limiting Membrane and Ellipsoid Zone in Diabetic Macular Edema: A Population AI-Assisted Optical Coherence Tomography Study

Purpose: To investigate the behavior of the external limiting membrane (ELM) and ellipsoid zone (EZ) in diabetic macular edema (DME) using artificial intelligence (AI)-based optical coherence tomography (OCT) quantification. Methods: This was a cross-sectional study. OCT scans of...

Osteitis Pubis in Athletes in the Era of Pubic-Related Groin Pain: Contemporary Concepts in Diagnosis, Rehabilitation, and Surgical Decision-Making

Background: Osteitis pubis (OP) is a recognized contributor of anterior pelvic and groin pain, particularly in athletic populations, and is currently included within the wider spectrum of pubic-related groin pain. Despite the growing body of literature, clinical management is sti...

Adelmidrol plus hyaluronic acid injections in the management of shoulder impairment due to rotator cuff disease: an exploratory pilot observational retrospective investigation

BACKGROUND: Shoulder disorders are the third most common musculoskeletal presentation in primary care. Injuries to the structures surrounding this joint are closely related to oxidative stress and can lead to rotator cuff (RC) disease, including subacromial impingement syndrome,...

Aflibercept 8 mg for diabetic macular edema and neovascular age-related macular degeneration: an italian expert consensus paper

To provide consensus recommendations on the clinical use of aflibercept 8 mg in managing neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME) in the real-world setting. A modified Delphi study was undertaken, involving ophthalmologists from special...

Development and benchmark validation of PubChat for PubMed-grounded multilingual biomedical literature retrieval

The rapid growth of biomedical literature has rendered traditional systematic reviews unsustainable. Although large language models (LLMs) offer automation potential, citation fabrication and unreliable evidence discrimination remain critical barriers. Here, using PubChat as a Pu...

HPV DNA negativity following AHCC or nonavalent vaccination or their combination in women with persistent HPV infection without HSIL

Persistent infection with high-risk human papillomavirus (HR-HPV) is a common clinical condition for which no validated systemic antiviral therapy is currently available, and in the absence of high-grade cervical lesions management is generally limited to surveillance. Active Hex...

Development and Internal Validation of a Clinical Risk Score for Hypovitaminosis D in Italian Adults Aged ≥50 Years Attending Osteoporosis and Metabolic Bone Disease Centers

Background/Objectives: Hypovitaminosis-D is a highly prevalent condition worldwide, associated with adverse skeletal and extra-skeletal outcomes. Increasing demand for serum 25-hydroxyvitamin D (25(OH)D) testing points toward the need for simple tools to identify individuals at r...

Supporting upper limb movements with a soft robot after a brachial plexus injury

Brachial plexus injury causes severe arm weakness, forcing patients to rely on compensatory movements for daily activities. Most robotic solutions target isolated elbow or hand function, whereas multi-joint assistance remains limited. Here we show that a soft wearable exosuit pro...

Effectiveness of Therapeutic Sport Footwear in Prevention of Ulcer Recurrence in Persons with Diabetic Foot Disease

Recurrence of diabetic foot ulcer (DFU) remains a major clinical challenge in patients with diabetes. Therapeutic footwear is a cornerstone of secondary prevention as it reduces plantar pressure and mechanical stress. However, most available evidence focuses on traditional orthop...

Evaluation of Dual-Near-Infrared-Wavelength Photobiomodulation Therapy for the Treatment of Canine Otitis Externa: A Prospective Multicenter Pilot Study

This is the first prospective multicenter study investigating photobiomodulation (PBM) in canine OE. Inclusion criteria required an Otitis Index Score 3 (OTIS-3; scale 0–3) ≥1 for erythema and discharge and a Budach cytological score ≥1+ (scale 0–4+) for Malassezia spp. and/or ba...