CS Diagnostics

Evaluation and Optimization of Different DigestionStrategies for In-Depth Proteomic Characterization of Residual HostCell Proteins in rAAV-Based Gene Therapy Products

Abstract Recombinant adeno-associated virus vectors (rAAVs) are the most important vectors for in vivo gene therapies, yet their safety relies on low levels of residual host cell proteins (HCPs). While mass spectrometry-based proteomics enables sensitive and untargeted HCP profil...

Post-Operative Magnetic Resonance Imaging of Canine Cervical Spine After Ventral Slot Surgery; Evaluation of the Porcine-Derived Hemostatic Compound Spongostan™ Specific Imaging Features

Porcine-derived gelatin sponge SPONGOSTAN™ is an adjunct material routinely used in neurosurgery. This study aimed to describe its MRI features, since its imaging features are not available yet in veterinary medicine. Post-operative MR images of dogs that underwent decompressive...

A Technology-Blended Exercise Intervention for Cognitive Risk Reduction and Brain Health in Middle-Aged and Older Adults with Type 2 Diabetes in Singapore

BACKGROUND: Type 2 diabetes mellitus (T2DM) is a major modifiable risk factor for accelerated brain ageing, cognitive decline, and dementia. However, sustainable lifestyle interventions targeting cognitive health in at-risk older adult populations remain limited. This mixed-metho...