Creighton University

Outcomes of heart failure hospitalizations in adults with heterogeneous subtypes of muscular dystrophy: a nationwide analysis in the united states

Muscular dystrophies (MDs) may cause heart failure (HF), but outcomes specific to MD-related HF are poorly characterized. We evaluated outcomes of HF hospitalizations in patients with MDs compared to patients without MD in the United States. Discharge data from HF hospitalization...

Gamified Augmented Sensorimotor Feedback During Balance Training Improves Postural Control and Nocturnal RMSSD

Background and Objectives: Augmented sensorimotor feedback may enhance motor learning during balance training, but whether these adaptations extend to cardiac autonomic regulation remains unclear. This study compared wobble-board training with gamified augmented feedback versus c...

Predictive Performance of Screening Methods for Neonatal Opioid Withdrawal Syndrome

BACKGROUND: Routine urine substance screening (USS) in pregnant women for perinatal substance exposure is associated with bias and has limited evidence supporting its use. We evaluated agreement between maternal disclosure, maternal and neonatal USS, and their predictive abilitie...

Complement Proteins C1q-C5 as Context‑Dependent Regulators of Osteoblast Function and Fracture Healing: A Systematic Review

Background Complement proteins (C1q–C5) participate in immune surveillance and inflammation, but their roles in osteoblast biology and fracture healing remain generally undefined. Emerging evidence suggests that complement activation may exert both pro‑regenerative and pro‑inflam...

Resolving Host-Associated Antimicrobial Resistance in Municipal Wastewater Using Hi-C Metagenomics

Conventional wastewater metagenomics enables population-level surveillance of antimicrobial resistance (AMR) but provides limited insight into the bacterial hosts, genomic context, and the mobility of resistance determinants. In this study, we applied high-throughput chromosome c...

Physicians attitudes towards mental health and self-reported rates of anxiety, depression, and alcohol use

Physicians, including medical students, experience substantial occupational stressors associated with increased risk of depression, anxiety, and substance use disorders. Despite growing attention to clinician well-being, stigma surrounding mental illness remains a barrier to help...

Neural oscillatory responses to angry and neutral expressions become weaker with aging in face-sensitive regions

Emotion processing remains relatively intact throughout life, seemingly becoming more positive with age. Facial expressions reflect different emotions and involve distinct oscillatory responses, but whether aging affects these remains unclear. Using magnetoencephalography, we exa...

Asymmetrical bilateral ureteral duplication: a cadaveric case report illustrating the clinical implications of a rare congenital urinary tract anomaly

Abstract Background Ureteral duplication is among the most common congenital anomalies of the kidney and urinary tract; however, asymmetrical bilateral ureteral duplication, characterized by complete duplication on one side and incomplete duplication on the contralateral side, ha...

Myocardial Infarction Within 6 Months Before Arthroscopic Rotator Cuff Repair Is Associated With Significantly Increased Risk of Postoperative Myocardial Infarction

Purpose To evaluate the association between myocardial infarction (MI) timing within 2 years prior to arthroscopic rotator cuff repair (aRCR) and postoperative cardiac, medical, and surgical complications. Methods The PearlDiver Mariner Database (2010‐2022) was queried to identif...

DWI-FLAIR mismatch versus perfusion-based selection for extended window thrombolysis in acute ischemic stroke: a meta-analysis of randomized controlled trials

To compare efficacy and safety outcomes of DWI–FLAIR mismatch versus CT/MR perfusion-based selection for intravenous thrombolysis (IVT) in extended-window acute ischemic stroke (AIS), we performed a systematic review and meta-analysis of randomized controlled trials enrolling adu...

Reinforced Polyester Patch Augmentation Improves Biomechanical Properties of Thin Fascia Lata Grafts for Superior Capsule Reconstruction

Purpose To investigate the effect of reinforced polyester patch augmentation on the biomechanical characteristics of thin fascia lata graft. Methods Three graft types were made from fascia lata: (1) thin graft; (2) thin graft augmented with a reinforced polyester patch placed bet...

Neutropenic Diet Versus Liberalized Diet in Patients With Cancer: A Systematic Review and Meta-Analysis

Purpose Neutropenic diet (ND) has historically been recommended to reduce infectious complications in patients with cancer. Although its use has declined over the past decade, recent studies, particularly in patients undergoing hematopoietic stem-cell transplantation (HSCT), have...

Radiology considerations for the PREMIUM study: a multicenter randomized controlled trial of abbreviated MRI versus ultrasound for liver cancer screening in cirrhosis

Abstract This paper describes the rationale and radiology considerations in the implementation of the Preventing Liver Cancer Mortality through Imaging with Ultrasound versus MRI (PREMIUM) study. PREMIUM is a multicenter, randomized controlled trial sponsored by the Department of...

Opioid Overdose Risk and Recovery Barriers: A Mixed Methods Study of Perspectives From a Community

Objectives: According to the Centers for Disease Control and Prevention, opioid-related deaths in the United States have increased steadily during the past 20 years, contributing to a major public health emergency. In Nebraska’s most populous county, Douglas County, the drug over...

Exploring the Association Between Colorectal Cancer Metastasis and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Nationwide Analysis

Background: Metabolic syndrome-associated conditions and malignancies frequently co-exist, influencing each other’s progression, severity, and prognosis. This study evaluates whether metabolic dysfunction-associated steatotic liver disease (MASLD) contributes to an increased risk...

Peroneal Muscle Size and Quality Changes after Impairment-Based Rehabilitation in Patients with Chronic Ankle Instability

Background Peroneal muscles are the primary stabilizers against ankle inversion movements associated with lateral ankle sprains. Individuals with chronic ankle instability (CAI) demonstrate peroneal muscle deficits including decreased strength, slower nerve conduction velocity, a...

The Right Key, the Wrong Lock: TIGIT Checkpoint Blockade and the Road to Precision Immunotherapy

T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM) domains (TIGIT) emerged as one of the most promising next-generation immune checkpoint targets following the success of programmed cell death protein 1 (PD-1), programmed death-lig...

Standard Antiplatelet Therapy Versus Thrombolysis in Acute Spontaneous Spinal Cord Infarction: A Propensity Score–Matched Analysis

BACKGROUND: Spinal cord infarction (SCI) is a rare stroke subtype with no established acute treatment guidelines. Thrombolytic therapy has been used empirically based on extrapolation from cerebral stroke protocols, but comparative effectiveness data are lacking. We compared outc...