CReATe Fertility Centre

Autoantibodies to the Sodium/Potassium Pump Alpha-1 Subunit AT1A1 Identify At-Risk Pregnancies That Will Develop Fetal/Congenital Heart Block: Evidence and Translational Plan

Objectives Autoimmune congenital heart block (CHB) has been associated with maternal autoimmune disease for a century, particularly in lupus and Sjögren’s disease pregnancies. Although 80+% of affected pregnancies are anti-Ro positive, CHB develops in only 1 in 50 such pregnancie...