CReATe Fertility Centre

Altered sperm DNA methylation provides an epigenetic route from overweight and older men to intergenerational disease transmission

The occurrence of childhood neurodevelopmental disorders has been steadily increasing for decades, yet we have little understanding of modes of inheritance implicated in these diseases. Epidemiology studies have revealed an association between an elevated paternal Body Mass Index...

Autoantibodies to the Sodium/Potassium Pump Alpha-1 Subunit AT1A1 Identify At-Risk Pregnancies That Will Develop Fetal/Congenital Heart Block: Evidence and Translational Plan

Objectives Autoimmune congenital heart block (CHB) has been associated with maternal autoimmune disease for a century, particularly in lupus and Sjögren’s disease pregnancies. Although 80+% of affected pregnancies are anti-Ro positive, CHB develops in only 1 in 50 such pregnancie...