County Hospital

Homoisoflavanones, Alkaloid, and Norsesquiterpenoid from Polygonatum cyrtonema and Their Immunomodulatory Effects

Abstract Polygonatum cyrtonema (Huang jing) is widely used in both the food and traditional Chinese medicine industries. A chemical investigation of the rhizome of cultivated P. cyrtonema yielded six previously undescribed compounds─one norsesquiterpenoid (1), one pyridine alkalo...

Incidence, prevalence and outcomes of neonatal sepsis: a population-based cohort study of hospitalized neonates in Huai’an, China

Background This study aims to estimate the incidence, prevalence of morbidity and mortality rate (MR), associated risks, and the applicability of neonatal sequential organ failure assessment (nSOFA), of neonatal sepsis from a database of all hospitalized infants in a representati...

Malignancies in horseshoe kidneys: an updated review

Out of over 4000 available studies about horseshoe kidney (HSK), we selected 89 representative articles that emphasized the most common genetic lesions and tumors that can occur in these patients. Renal cell carcinomas, carcinomas of the urothelial tract, and Wilms tumor are the...

The relationship between inflammation and multiple myeloma: insights into alterations and prognostic value

Abstract Multiple myeloma (MM) is an inflammation-driven plasma cell malignancy influenced by the bone marrow microenvironment. Dysregulated cytokine networks and neuroimmune factors may contribute to disease progression and extramedullary disease (EMD), a high-risk variant with...

The relationship between biological rhythm disturbances and mixed features in major depressive episodes: a multicenter cross-sectional study

Major depressive episodes (MDEs) with mixed features are associated with greater clinical complexity and may represent an important indicator of bipolarity. Biological rhythm disturbances have been implicated in mood disorders, but their relationship with mixed features during MD...

Voice-Based Screening of Depression and Anxiety Using Machine Learning and Deep Learning: A Scoping Review of Methods and Clinical Readiness

Despite the high global prevalence of depressive and anxiety disorders, access to early clinical assessment remains limited for many. Although this field has grown rapidly, existing reviews have focused primarily on technical performance, with limited systematic attention to whet...

Nanobubbles in environmental remediation and sustainable technologies: A comprehensive overview of mechanisms, applications, and future prospects

Nanobubbles (NBs) are unique gas-filled colloidal systems with significant potential for environmental remediation and sustainable resource management applications. Unlike conventional aeration or solid nanomaterials, NBs provide a high interfacial area, extended residence time,...

Clinical Outcomes of Fixed Dental Prostheses Supported by Teeth or Implants in the Posterior Region—A Long‐Term Retrospective Multicenter Study

BACKGROUND: Few long-term studies compare tooth- and implant-supported fixed dental prostheses (FDPs) in the posterior region. OBJECTIVES: To compare the 5- and 10-year survival and complication outcomes of tooth- and implant-supported FDPs and to assess patient-reported effects....

Comparison of the Alvarado Score with Alternative Diagnostic Tools in Pediatric Acute Appendicitis: A Literature Review

Background: Acute appendicitis is a leading pediatric surgical emergency. Timely diagnosis remains challenging, particularly in young children with atypical presentations. Clinical evaluation alone yields variable diagnostic performance, prompting the use of risk stratification t...

Contrast-enhanced high-resolution magnetic resonance imaging for predicting recanalization in non-acute middle cerebral artery occlusion

The potential predictive value of contrast-enhanced high-resolution magnetic resonance-vessel wall imaging (MR-VWI) for endovascular recanalization in patients with non-acute middle cerebral artery (MCA) occlusion remains unclear. We retrospectively enrolled consecutive patients...

Association between perioperative D-dimer dynamics and post-treatment localized intravascular coagulation in venous malformations

OBJECTIVE: To investigate the association between the change in D-dimer levels (ΔD-dimer) and the development of localized intravascular coagulation (LIC) following surgical intervention in patients with venous malformations. METHODS: This retrospective cohort study enrolled 267...