Corporación Universitaria del Meta

Order–disorder interfaces in viral pRb inactivation: molecular dynamics insights into SLiM-mediated recognition and implications for interaction databases

Intrinsically disordered regions (IDRs) mediate protein interactions through poorly understood mechanisms. We studied the retinoblastoma protein (pRb) and its interaction with the SV40 Large T antigen (LTSV40), a viral oncoprotein that displaces E2F factors. Using molecular dynam...

Order–disorder interfaces in viral pRb inactivation: molecular dynamics insights into SLiM-mediated recognition and implications for interaction databases

Intrinsically disordered regions (IDRs) mediate protein interactions through poorly understood mechanisms. We studied the retinoblastoma protein (pRb) and its interaction with the SV40 Large T antigen (LTSV40), a viral oncoprotein that displaces E2F factors. Using molecular dynam...