Cork University Hospital

The EnPlace® Device for Advanced Apical Prolapse: Anatomical Outcomes and Long-Term Satisfaction

Background: Apical pelvic organ prolapse remains a considerable surgical challenge given its comparatively high recurrence rates. The EnPlace® device provides a mesh-free, minimally invasive option for sacrospinous ligament fixation (SSLF). This study evaluates the long-term safe...

Gut microbial metabolism of peanuts generates immunoregulatory metabolites

Background. Complementary feeding practices and timing are thought to significantly influence early life immune development, with the early introduction of allergenic foods being especially important for prevention of food allergy. We hypothesized that allergen-containing foods s...

Preparing the next generation of dental leaders: a scoping review

Aims With ongoing uncertainty about how dental leadership should evolve to meet future real-world challenges, this rapid scoping review evaluated existing literature to identify strategies that most effectively develop leadership skills in dentistry. Methods Multiple sources (Med...

Longer hospital stay but similar one-year mortality and readmission after combined proximal humerus and proximal femur fragility fractures: a Propensity-Score–Matched Cohort Study

Abstract Background Fragility Proximal Humerus (PH) fractures are common and often associated with significant morbidity and mortality. Unlike Proximal Femur (PF) fractures, PH fractures are often omitted from established orthogeriatric multidisciplinary team (MDT) pathways. Comb...

Longitudinal health-related quality of life after electrochemotherapy in elderly patients with cutaneous melanoma

The incidence of cutaneous melanoma (CM) is increasing among elderly patients, who often present with advanced disease, including cutaneous metastases. Electrochemotherapy (ECT) is a local ablative treatment that enhances chemotherapy uptake via electric pulses. Management in pat...

Enhanced cognitive behavioural therapy for suicidality among people with comorbid mental and physical health conditions: study protocol of a pragmatic randomised controlled trial

Suicidal behaviours represent significant public health concerns. People who present with suicidal ideation and/or self-harm are at an increased risk of suicide. The presence of co-existing or comorbid mental and physical health conditions, coupled with neurobiological factors, e...

International Comparison of Ambulance Time Intervals for Suspected Stroke/Transient Ischemic Attack Across 7 Emergency Medical Services Before and During the COVID‐19 Pandemic

BACKGROUND: International reports highlight the COVID-19 pandemic's wide-ranging impacts on time-sensitive conditions, including stroke/transient ischemic attack (TIA). Comparing ambulance time intervals globally offers insights into COVID-19's effects on different health care sy...

SKY92 Identifies High‐Risk Newly Diagnosed Multiple Myeloma With Inferior Progression‐Free Survival and Implicates NUF2 as a Candidate Driver

ABSTRACT Objectives To determine the prevalence and prognostic significance of the SKY92 gene‐expression signature, evaluate minimal/measurable residual disease (MRD), and identify molecular drivers of high‐risk disease in transplant‐eligible newly diagnosed multiple myeloma (TE‐...