Cooperative Trials Group for Neuro-Oncology

The amyloid plaque proteomes of Alzheimer’s disease and mild cognitive impairment

Amyloid plaques contain numerous proteins in addition to amyloid beta in Alzheimer’s disease (AD). Previous localized proteomics identified plaque-associated proteins in late-onset AD, early-onset AD, rapidly progressive AD, preclinical AD, and AD in Down syndrome, although most...

Photoreactive Pantetheinyl Mimics Reveal Design Limitations for Crypto‐Acyl Carrier Proteins

Polyketide synthases (PKS), fatty acid synthases (FAS), and non-ribosomal peptide synthetases (NRPS) span a variety of protein architectures and catalytic modalities. Common to all these biosynthetic modalities is the centrality of a phosphopantetheinylated carrier protein, which...

Vitamin D supplementation for prevention of vitamin D deficiency in preterm and low birth weight infants

RATIONALE: Infants born prematurely or low birth weight (LBW) are at increased risk of vitamin D deficiency, poor bone health and rickets. Uncertainty exists regarding the need, dose and duration of vitamin D supplementation in preterm and LBW infants. OBJECTIVES: To evaluate the...

Do carers of people with a chronic illness desire and seek psychological support? A quantitative systematic review

OBJECTIVE: This review systematically quantified engagement with psychological services among carers of people with chronic physical illness by determining the (a) prevalence and correlates of interest in, intention to access and use of services; and (b) availability of carer-spe...

Lived experience leadership in cancer research: a scoping review of conceptual definitions, roles, responsibilities, and impacts

Abstract Background The meaningful integration of lived experience expertise into cancer research is increasingly recognized as essential to improving research relevance, quality, and impact. However, the extent to which people with lived experience of cancer hold leadership role...

Fibrinogen Early In Severe Trauma studY II (FEISTY II): study protocol for a randomised clinical trial of fibrinogen concentrate vs cryoprecipitate in traumatic haemorrhage in Australia and New Zealand

Haemorrhage is a leading cause of preventable death amongst severe trauma patients and is often complicated by hypofibrinogenaemia. Fibrinogen replacement can be achieved using fibrinogen concentrate (FC) or Cryoprecipitate (Cryo), but comparative evidence in traumatic haemorrhag...