Cooperativa de Ensino Superior Politécnico e Universitário

Determination of Pyrrolizidine Alkaloids in Tea and Herbal Infusions by LC-MS/MS

Pyrrolizidine alkaloids (PAs) and N-oxides (PANOs) are food-safety hazards subject to regulatory limits, and their occurrence in teas and herbal infusions (THI) represents a dietary route. This study aimed to develop and validate a liquid chromatography-tandem mass spectrometry (...

Fully Automated Artificial Intelligence-Based Design Single Tooth-Supported Dental Crowns: A Systematic Review of Efficiency, Fit, and Morphological Accuracy

Abstract Fully automated artificial intelligence (AI)-based dental crown design has recently emerged as an alternative to conventional workflows, including technician-assisted digital design and traditional wax-up techniques. However, the available evidence remains heterogeneous,...

The Canine Leishmaniosis Proteinogram: A Reference Serum Electrophoretic Atlas of 5544 Dogs over 18 Years

Serum protein capillary electrophoresis can characterise dysproteinaemia in dogs tested for canine leishmaniosis (CanL) as an integrated clinicopathological phenotype of humoral immune activation. This retrospective laboratory-based study evaluated serum protein electrophoretic p...

Beyond Modified Transudates: Diagnostic Performance of the Feline Infectious Peritonitis Effusion Index on the Sysmex XN-1000V

The antemortem clinical and clinicopathological diagnosis of feline infectious peritonitis (FIP) remains challenging, particularly when effusions deviate from the classically protein-rich, low-to-moderate-cellularity phenotype. The FIP Effusion Index, defined as the ratio of delt...

Resistant Candida spp. in Healthy Individuals: Mapping a Surveillance Blind Spot

The prevalence and characteristics of resistant, biofilm-forming Candida strains in healthy individuals remain poorly understood. In this work, Candida strains from 23 healthy volunteers and 11 candidiasis patients (n = 34) were isolated and characterized. Biofilm formation capac...

Explainable machine learning for neurocognitive severity clustering and multivariable profiling after acute coronary syndrome

Neurocognitive impairment is a frequent complication of Acute Coronary Syndrome (ACS). Current research often treats cognitive decline as a monolithic outcome, failing to account for the heterogeneous ways in which psychosocial and clinical factors interact to form distinct patie...

Early mechanical changes of limb muscle in septic shock assessed by dual-plane shear-wave elastography

Abstract Background Septic shock induces skeletal muscle wasting and neuromuscular dysfunction, contributing to ICU-acquired weakness (ICUAW) and poor recovery after critical illness. Conventional ultrasound primarily captures structural changes but provides limited insight into...

Preclinical Evaluation of Combined Polo-like Kinase 1 Inhibition and Navitoclax in Experimental Models of Lung Cancer

Targeted therapies have substantially advanced cancer treatment; however, therapeutic resistance remains a major challenge, particularly in lung cancer. Polo-like kinase 1 (PLK-1), a key regulator of mitosis, is frequently overexpressed in lung tumors and has emerged as an attrac...

Impaction and Mineralization Status of the Mandibular Third Molar: A Retrospective Study

Chronological age estimation is used in legal contexts to determine the transition between minor and adult status, with the third molar (3M) being a primary biological indicator. This retrospective study aimed to analyze the relationship between the topographic position of impact...

The Use of Ozone Therapy or Blue®M Gel as an Adjunctive Therapy in Patients With Periodontal Disease: A Systematic Review

Background: Conventional treatment of periodontal disease is based on subgingival instrumentation, but its limited effectiveness in eliminating certain pathogens has led to the need for adjuvant approaches such as ozone therapy (OT) or Blue®m gel. Methods: A systematic review was...