Cooperativa de Ensino Superior Politécnico e Universitário

Preclinical Evaluation of Combined Polo-like Kinase 1 Inhibition and Navitoclax in Experimental Models of Lung Cancer

Targeted therapies have substantially advanced cancer treatment; however, therapeutic resistance remains a major challenge, particularly in lung cancer. Polo-like kinase 1 (PLK-1), a key regulator of mitosis, is frequently overexpressed in lung tumors and has emerged as an attrac...

Impaction and Mineralization Status of the Mandibular Third Molar: A Retrospective Study

Chronological age estimation is used in legal contexts to determine the transition between minor and adult status, with the third molar (3M) being a primary biological indicator. This retrospective study aimed to analyze the relationship between the topographic position of impact...

The Use of Ozone Therapy or Blue®M Gel as an Adjunctive Therapy in Patients With Periodontal Disease: A Systematic Review

Background: Conventional treatment of periodontal disease is based on subgingival instrumentation, but its limited effectiveness in eliminating certain pathogens has led to the need for adjuvant approaches such as ozone therapy (OT) or Blue®m gel. Methods: A systematic review was...