Convergence

Tear-Based Dynamic Network Biomarkers for Pre-Disease Detection of Hyperuricemic Nephropathy via Smart Contact Lens

Abstract Early identification of the pre-disease state is critical for effective intervention and improved outcomes in chronic kidney disease. However, current diagnostic approaches mainly rely on serum-based biomarkers, which are limited in capturing dynamic physiological change...

Targeting the Candida albicans agglutinin-like sequence 3 adhesin to disrupt oral polymicrobial bacterial–fungal biofilms: mechanisms and therapeutic strategies

glucosyltransferases is examined in detail. Emergent properties of Als3-dependent oral co-biofilms, including elevated antimicrobial tolerance, architectural complexity, metabolic interdependence, and interkingdom signaling amplification, are analyzed. Therapeutic strategies revi...