Consorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase

Synergistic π–π Stacking and Hydrogen Bonding of Doxorubicin Electrostatically Bound to Sodium Alginate Drive the Formation of Supramolecular Nanoparticles with Exceptional Drug Loading

Doxorubicin hydrochloride (DX) is a widely used chemotherapeutic agent whose severe side effects can be attenuated by suitably designing drug delivery systems. The complexation between DX and the biocompatible and biodegradable sodium alginate (ALG) results in the formation of DX...

Maternal SARS-CoV-2 exposure and neonatal metabolic maturation during the first month of life: a longitudinal urinary metabolomics study

Abstract The first month of life is characterized by rapid metabolic adaptation as neonates transition from intrauterine to extrauterine life. Whether maternal SARS-CoV-2 infection influences these developmental trajectories remains largely unexplored. In this longitudinal study,...

Selective Packaging of miR‐22 and miR‐29 Orthologues into Extracellular Vesicles of the Porcine Whipworm Trichuris Suis

ABSTRACT Helminths modulate host immunity, and in this respect, the porcine whipworm Trichuris suis has been explored clinically as an immunotherapy for inflammatory diseases. T. suis secretes a complex mixture of excretory/secretory products (ESP), including extracellular vesicl...

A Multinuclear 1H and 31P NMR Approach for Quantification of Pneumococcal Cell-Wall Polysaccharide in Vaccine Development

Abstract Capsular polysaccharides are the principal constituents of S. pneumoniae capsules and major determinants of bacterial virulence. As key antigenic targets, they represent the foundation for pneumococcal vaccine development. Cell wall polysaccharides (CWPSs) commonly persi...