Comprehensive Cancer Center Vienna

Regional Brain Injury Burden on Term-Equivalent MRI Is Associated with Neurodevelopmental Outcome in Extremely Preterm Infants with Intraventricular Hemorrhage

Background/Objectives: Extremely preterm infants remain at high risk of adverse neurodevelopmental outcomes, particularly in the presence of intraventricular hemorrhage (IVH) and associated brain injury. Term-equivalent cerebral magnetic resonance imaging (cMRI) provides a detail...

Clinical management of metachromatic leukodystrophy cases identified in the German and Austrian Newborn screening pilots

Abstract Background Metachromatic leukodystrophy (MLD) is a rapidly progressive leukodystrophy that leads to severe disability and early death if untreated. Autologous hematopoietic stem and progenitor cell gene therapy (HSPC-GT, atidarsagene autotemcel, arsa-cel) for early onset...

A DNA methylation–based risk score improves prognostic stratification in myelodysplastic neoplasms

Myelodysplastic neoplasms (MDS) are clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytopenias, and variable risk of progression to acute myeloid leukemia (AML). Although mutational data are already implemented into the most recent MDS risk models, (i.e...

Brainstem size in extremely preterm infants: reference values and association with neurodevelopmental outcomes

Abstract Background and objectives Extremely preterm infants are at high risk for neurodevelopmental impairment. The brainstem plays a critical role in early development. This study aimed to establish reference values for two-dimensional brainstem measurements on cerebral magneti...

Re‐evaluating impaired consciousness in temporal lobe epilepsy: The role of language dominance and network reorganization

Abstract Objective Temporal lobe epilepsy (TLE) frequently affects clinically‐classified ictal consciousness, which the 2025 International League Against Epilepsy (ILAE) classification operationalizes through clinical assessment of awareness and responsiveness. It remains uncerta...

International Society of Urological Pathology Multidisciplinary Expert Consultation Conference on Evaluation of Treatment Effects in Prostate and Bladder Cancer

Treatment effects in the urinary bladder are variable and range from localized post-transurethral resection changes to widespread systemic therapy effects. The International Society of Urological Pathology (ISUP) organized a consensus meeting in Vienna, Austria, in September 2025...

Cerebral glucose utilisation during musical emotions: A multimodal functional PET/MRI study:A multimodal functional PET/MRI study

Functional magnetic resonance imaging (fMRI) studies have demonstrated music-induced activation of the blood-oxygen-level-dependent (BOLD) signal across brain networks associated with auditory perception, motor control, and emotion. However, BOLD-fMRI reflects vascular responses...

High-grade serous ovarian cancer is associated with increased TP53 mutation burden in uterine lavage

High grade serous ovarian cancer (HGSC) has low survival partly due to the lack of methods for detection, diagnosis, and risk prediction. TP53 mutations, which drive HGSC, are found in gynecological tissues as the result of somatic evolution, but it is unknown whether an excess o...

Malaria Transmission Via Needle Stick Injury

We present the case of an 11-year-old boy with severe Plasmodium falciparum malaria, whose attending doctor sustained a needle stick injury (NSI) during phlebotomy. We also report the findings of a systematic literature review of papers describing malaria transmission to healthca...