Colorado School of Public Health

Real-world cardiovascular effects of liraglutide: transportability analysis of the LEADER trial

Abstract Appropriate use of recently approved type 2 diabetes treatments depends on external validity of landmark clinical trials (RCTs) in real-world populations that may differ from trial participants. This study transported effect estimates from the Liraglutide Effect and Acti...

Behavioral nudges and feedback lead to improved pre-primary teacher practices in Kenya

Many national pre-primary curricula call for classroom practices that support children’s autonomy and teacher-child dialogue, but these practices are observed inconsistently. Teachers in low-resource settings often lack affordable, scalable support and professional development to...

An Fc receptor and IgA functional signature identifies TB disease in children living with HIV

Abstract Background Tuberculosis (TB) is a leading cause of morbidity and mortality among children living with HIV (CLHIV). TB disease is difficult to detect with current clinical microbiological, immunological, and radiographic tools. Serological assays that determine levels of...

Ultra-high dimensional confounder selection algorithm comparison, with application to radiomics data

Radiomics is an emerging area of medical imaging data analysis for diseases such as cancer. It involves the conversion of digital medical images into mineable ultra-high dimensional data, where, the number of extracted radiomics features is much larger than the number of observat...

Menopause in the All of Us Research Program: a descriptive summary of electronic health record and survey response across sociodemographic characteristics

ABSTRACT Objective Menopause is a significant physiological transition with implications for health outcomes (e.g., cardiometabolic), yet gaps remain in understanding the menopause transition, including how menopause timing and type influence health outcomes. Large-scale cohort s...

Potential Harms of Ocular and Periorbital Topical Vitamin A Application: A Systematic Review and Meta-Analysis

Purpose: Topical vitamin A derivatives (retinoids) are widely used for dermatologic and cosmetic indications and are often applied to the face and periorbital region. Although vitamin A is essential for epithelial integrity and tear film homeostasis, concerns exist regarding pote...

Omic risk scores are associated with COPD-related traits across three cohorts

Background: Chronic obstructive pulmonary disease (COPD) exhibits marked heterogeneity in lung function decline, mortality, exacerbations, and other disease-related outcomes. Omic risk scores (ORS) estimate the cumulative contribution of omics, such as the transcriptome, proteome...

Prenatal Water Fluoride Exposure and Children’s Behavioral Problems

Importance Although fluoride exposure at high levels during the perinatal period has been associated with socioemotional problems among children, there is limited evidence regarding potential associations at lower levels of fluoride exposure, particularly in the US. Objective To...

Extreme Risk Protection Orders Among Military Service Members and Veterans

Importance Service members and veterans who die by suicide disproportionately use firearms. Extreme risk protection orders (ERPOs) temporarily restrict firearm access for individuals deemed at risk of harming themselves or others. Despite elevated firearm-suicide risk among servi...

Comparison of Machine Learning-Based Reporting with Surgeon Reporting of Postoperative Complication in Cardiothoracic Morbidity and Mortality Conferences

BACKGROUND: Traditional morbidity and mortality (M&M) conferences incompletely capture postoperative complications, potentially limiting quality improvement efforts. We developed and validated the Automated Surveillance of Postoperative Infectious and Non-Infectious Complications...

Using a systematic review of youth and environmental youth participatory action research outcomes to create a modified implementation capacity framework

While youth participatory action research (YPAR), a youth-adult partnered or youth-led approach to knowledge generation and social change, has burgeoned over the last decade, challenges remain related to capacity for its implementation. Yet, the field lacks a YPAR implementation...

Multi-Omic Spectral Clustering with the Flag Mean

Abstract Motivation One common goal in multi-omics studies is to identify subgroups within the study’s cohort. Many methods create subgroups through unsupervised clustering, and, to our knowledge, all of these methods attempt to infer a common subspace or latent cluster across mu...

Autonomous Oxygen Titration for Maintaining Normoxemia in Acutely Ill Adults

Importance For acutely ill adults who are hospitalized with hypoxemia, supplemental oxygen is titrated to maintain normoxemia. In current practice, clinicians intermittently titrate oxygen, potentially exposing patients to hypoxemia and hyperoxemia between assessments. Autonomous...