Collegium Medicum in Bydgoszcz

Alterations in 5hmC and TET2 expression in bladder cancer and their associations with clinicopathological features and patient outcome

Abstract Bladder cancer (BLCA) remains a major clinical challenge due to its high recurrence rate and the limited availability of reliable prognostic biomarkers. Since epigenetic dysregulation is a hallmark of urothelial carcinogenesis, we investigated the expression patterns, cl...

Filling the gaps in high-priority reference materials for implementing metrological traceability in laboratory medicine

Abstract The global harmonization of measurements in laboratory medicine is facilitated by the development and implementation of reference measurement systems, including suitable certified reference materials (CRMs). There are, however, a relatively small number of CRM producers...

Effect of Dupilumab on Allergen-Specific IgE Levels and Clinical Tolerance in Patients with Food Allergy: A Systematic Review

Food allergy is a growing global health concern associated with significant dietary restrictions, impaired quality of life, and risk of severe allergic reactions. Dupilumab, a monoclonal antibody targeting the interleukin-4 receptor alpha (IL-4Rα), inhibits IL-4 and IL-13 signali...

A roadmap for standardization of serum albumin measurements

Abstract Albumin measurements in serum have important diagnostic and prognostic roles. However, non-standardized measurement procedures are still used in medical laboratories. An agreed approach for the implementation of metrological traceability to the International System of Un...

Circulating PDIA4, MMP-2, MMP-9, and Claudin-2 in Vitamin D-Deficient Patients with Brain Tumors: An Exploratory Clinical Pilot Study

Background/Objectives: Extracellular matrix remodeling, cellular stress responses, and blood–brain/blood–tumor barrier-related alterations are important processes involved in brain tumor biology. This exploratory cross-sectional pilot study evaluated circulating circulating prote...