Collège de France

Multiple motor proteins regulate TDP-43 anterograde axonal transport

TAR DNA-binding protein 43 (TDP-43) is an RNA-binding protein essential for RNA metabolism. Under physiological conditions, it predominantly resides in the nucleus but is also expressed in the cytoplasm, where it regulates mRNA trafficking and local translation. In nearly 97% of...

Computational identification and experimental validation of early glycinergic impairments in spinal muscular atrophy

Spinal Muscular Atrophy (SMA) is a progressive neurodegenerative disorder characterized by lower motor neuron (MN) loss, due to mutations or deletions in the Survival Motor Neuron 1 ( SMN1 ) gene. Increasing evidence implies mitochondrial dysfunctions in SMA, suggesting these org...

Universal random matrix behavior of a Fermionic quantum gas

Since its initial use by Wigner in describing heavy atom spectra, random matrix theory (RMT) has found applications and revealed universal laws in diverse physical contexts, from quantum field theory to disordered systems and wireless communications. A particularly compelling app...

Scalable ground-state certification of quantum spin systems via structured noncommutative polynomial optimization

A fundamental challenge in quantum physics is determining the ground-state properties of many-body systems. Whereas standard variational approaches posit a wave-function ansatz and minimize over the possible states expressible by that ansatz, the problem can alternatively be form...

Neural network–augmented Pfaffian wave-functions for scalable simulations of interacting fermions

Developing accurate numerical methods for strongly interacting fermions is crucial for improving our understanding of various quantum many-body phenomena, especially unconventional superconductivity. Recently, neural quantum states have emerged as a promising approach for studyin...

Neanderthal’s heel: How the Neanderthal’s external calcaneal shape uniquely differs from that of modern humans

Neanderthals exhibit unique morphological adaptations in their calcaneus compared to Homo sapiens , shedding light on distinct evolutionary pressures and functional requirements shaping their respective foot anatomy. This study assesses which calcaneal traits represent plesiomorp...