CNR de la Résistance aux Antibiotiques

Strengthening systems to monitor antibiotics. An action oriented approach

Background Antibiotics have become lynchpins of our modern systems of healthcare, animal health and agriculture. Monitoring the types and volumes of antibiotics distributed, used and discharged across these systems is critical to provide evidence for action. With limited resource...

Clinical and Epidemiological Profile of Children Evaluated at a Public Pediatric Cardiology Service in Southern Brazil

Background/Objectives: Congenital heart disease (CHD) is a major cause of congenital morbidity and mortality, but evidence from public pediatric cardiology services in Brazil remains limited. This study aimed to characterize the clinical and epidemiological profile of children an...

Targeting Both Oncogenic Signaling and Dependence Receptor Function is Required to Fully Suppress MET Exon 14 Skipping-Driven tumorigenesis

Abstract Receptor tyrosine kinases (RTKs) classically function as oncogenic drivers that promote survival and proliferation upon ligand binding. A subset of RTKs can also function as dependence receptors, inducing apoptosis in the absence of their ligands. Genetic alterations tha...

Knowledge, attitude, and practice of antifungal resistance and stewardship among pharmacy students in Zambia: a cross-sectional study to inform antifungal stewardship programs

Background Antifungal resistance (AFR) is a growing global health threat, particularly in low- and middle-income countries such as Zambia, where antifungals are often accessed without prescription. Antifungal stewardship (AFS) programs aim to optimise antifungal use, yet limited...

Carbapenemase-producing Klebsiella oxytoca complex in France (2017–2023): Molecular epidemiology integrated with virulence and biofilm phenotypes

OBJECTIVES: This study analysed a large French collection of carbapenemase-producing Klebsiella oxytoca complex (KoC) isolates (2017-2023) to map species and carbapenemase distributions and identify emerging lineages. We further investigated virulence traits to understand the epi...