CM Hospital

Clinical characteristics and prognosis of IgA nephropathy and comorbid diabetic kidney disease

AIMS: This study characterized clinical features, pathology, treatment, and prognosis of biopsy-confirmed coexisting IgA nephropathy (IgAN) and diabetic kidney disease (DKD). METHODS: = 80), matched on age, sex and baseline serum creatinine (sCr). Baseline clinical and pathologic...

Mendelian randomization and drug repurposing analysis identifies APOE as a potential therapeutic target for low back pain

Abstract Background: Low back pain (LBP) is a prevalent chronic pain syndrome primarily driven by spinal degeneration, causing persistent disability and reduced quality of life. Despite available interventions, identifying novel therapeutic targets remains imperative for modifyin...

A deep learning model utilizing H&E-stained images for predicting HER2-low expression in breast cancer

The development and clinical application of novel HER2-targeted antibody-drug conjugates (ADCs) have significantly improved outcomes for breast cancer patients with HER2-low expression. The efficacy of such therapies critically depends on accurate assessment of HER2-low status. H...