Clinique Saint Pierre

Serum neurofilament light chain and the 2024 McDonald criteria for multiple sclerosis: a retrospective cohort study

Background The 2024 McDonald criteria broaden the definition of multiple sclerosis (MS), enabling diagnosis in individuals with asymptomatic MRI findings or clinical presentations not meeting the 2017 criteria. We assessed whether these criteria identify such cases using independ...

Plasma p-tau217 in real-world clinical practice: distribution across clinical diagnostic categories, clinician confidence, and impact on care pathways

Plasma phosphorylated tau at threonine 217 (p-tau217) is a highly accurate blood-based biomarker for Alzheimer’s disease pathology, but evidence regarding its determinants and clinical impact in routine practice remains limited. We evaluated its distribution across real-world cli...

Amygdala shows heterogeneous atrophy and tauopathy patterns across the AD continuum

Abstract Background Amygdala shows early vulnerability in Alzheimer’s disease (AD), although its substructures have been less studied than hippocampal subfields. Neuropathological evidence suggests that tau pathology affects amygdala subnuclei differentially, yet in vivo characte...