Clinical Research Center Kiel

The FraiLtx Study Protocol: A Prospective, Single-Center Observational Study on Frailty, Systemic Inflammation, and Monocyte Subsets in Liver Transplant Candidates

Introduction: Frailty is a multidimensional syndrome characterized by diminished physiological reserve and increased susceptibility to stressors, resulting in poor perioperative outcomes. While commonly associated with elderly patients, frailty is increasingly recognized in liver...

A Scoring System Contributing to the Detection of Radiation Pneumonitis in Elderly Patients with Lung Cancer—Results of the POLCAR Trial

Background/Objectives: A symptom-based scoring system (0–9 points) for the identification of radiation pneumonitis was previously evaluated in lung cancer patients without age restrictions. A threshold of five points appeared optimal to detect pneumonitis. Since elderly patients...

Patient-reported outcomes after lateral unicompartmental and total knee arthroplasty: a propensity score-matched cohort study

Abstract Introduction Comparative evidence on patient-reported outcomes (PROs) after lateral unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA) remains limited. We compared PROs between cohorts matched for demographic characteristics and baseline knee func...

Buoyancy and polarity driven accumulation of dissolved organic matter in the sea surface microlayer during a phytoplankton bloom

Abstract. The sea surface microlayer (SML) is only 1–1000 µm thick but resembles a biologically and geochemically very active boundary that modulates the exchange of energy and matter between the ocean and atmosphere. Globally, the SML accumulates up to 200 Tg C yr−1 of organic m...

An Operator Algebra of Cognitive Memory Consolidation: Layered Composition, Lyapunov Stability, and the Cooperative-Survival Theorem

We develop an operator-algebraic account of memory consolidation in layered cognitive systems. Consolidation steps are modelled as operators on a memory state space; layering corresponds to composition, and the resulting algebra admits closure conditions under which a layered sys...

Minced cartilage implantation for cartilage regeneration: a survey of current clinical practices

INTRODUCTION: The objective of this study is to evaluate how minced cartilage implantation (MCI) is currently applied in clinical settings, focusing on the selection criteria, procedural execution, handling of concomitant joint pathologies, and postoperative management. MATERIAL...