Clifford Chance

Public Credit Guarantees, Financial Frictions, and Macroeconomic Stabilization: Evidence from Italy in the 2020–2022 Emergency Period

CLIFF SGR Research Center Working Paper No. 2026-01. This version was presented at the International Conference in Banking and Financial Studies (ICBFS 2026), University of Parma, 10 September 2026. A revised version is in preparation. Comments are welcome: research@cliffsgr.it....

Effect of a Machine Learning Algorithm to Guide Goal-Directed Therapy After Cardiac Surgery

Background Goal-directed therapy allows clinicians to optimize perfusion and volume status in patients postoperatively. Objective To evaluate the effect of a machine learning algorithm to guide postoperative goal-directed fluid therapy in cardiac surgery patients. Methods A goal-...

Targeting a CDH1–TK1–dependent DNA Synthesis Pathway Overcomes Chemoresistance in Acute Myeloid Leukemia

ABSTRACT Relapsed and refractory acute myeloid leukemia (AML) remains difficult to treat, in part because leukemic cells adapt to nucleoside analogue‐induced replication stress. Here, we identify thymidine kinase 1 (TK1) as a functional contributor to chemotherapy resistance in A...