Institution
Cleveland Clinic Lerner College of Medicine
Recent research
- Health & Medicine
Patient-reported outcome measures (PROMs) remain underutilized in musculoskeletal oncology, with only 4.9% of tumor-focused articles incorporating them. This review synthesizes current PROM instruments-including Toronto Extremity Salvage Score, PROMIS, and emerging tools such as...
- BiologyOpen access
Citron kinase activity controls alternative splicing events that drive prostate cancer growth
Prostate cancer (CaP) remains a major cause of cancer death in men, underscoring the need for mechanistically novel therapies. We previously identified the action of the mitotic kinase citron (CIT) kinase as a key driver of CaP progression and promising therapeutic target, but se...
- Health & Medicine
Brain volumetric signatures of neighborhood disadvantage in focal epilepsy
Abstract Objective Social disadvantage is an important determinant of health in focal epilepsy, but its neurobiological basis remains unclear. We examined whether brain morphometric alterations represent a structural signature of deprivation. Methods We performed a retrospective...
- Health & Medicine
ABSTRACT The goal of this American Rhinologic Society expert practice statement (EPS) is to provide an evidence‐based evaluation of the current literature on posterior nasal nerve ablation. Subtopics reviewed include the evidence for specific indications such as nonallergic rhini...
- Health & MedicineOpen access
Immunotherapy-Related Cardiac Arrythmias: Incidence, Pathobiology, Risk Factors and Management
Abstract Purpose of Review Immunotherapies have revolutionized treatment strategies for cancer patients, improving the prognosis in many populations with advanced malignancies. Immune check point inhibitors (ICI) and Chimeric antigen receptor (CAR) T cell therapy are being increa...
- Health & MedicineOpen access
Evolution of Endoscopic Spine Surgery: Contemporary Advances and Future Directions
Abstract Purpose of review Endoscopic spine surgery has evolved from non-visualized percutaneous discectomy only, into a comprehensive minimally invasive surgical platform with expanding indications across cervical, thoracic, and lumbar pathology. This review examines endoscopic...
- Health & MedicineOpen access
Abstract Current therapeutic interventions for Human African Trypanosomiasis (HAT) are severely limited by emerging drug resistance and profound systemic toxicity, necessitating the urgent development of novel chemotypes. Building upon our previous identification of the alpha-adr...
- Health & Medicine
Implementing Congenital CMV Screening in a Large Hospital System
BACKGROUND AND OBJECTIVES: Congenital cytomegalovirus (cCMV) is the most common congenital infection and the leading nongenetic cause of sensorineural hearing loss. Despite expanding legislative screening requirements across the United States, there is no consensus guidance on th...
- Society & EconomicsOpen access
Repurposing approved drugs for Alzheimer’s disease (AD) offers a cost-effective strategy to accelerate therapeutic development. This study characterizes the role of repurposed agents in the 2025 AD drug development pipeline. Data was obtained from clinicaltrials.gov using an auto...
- Health & MedicineOpen access
Detrusor Underactivity: Modern Definitions, Diagnostic Criteria, and Clinical Phenotyping
Abstract Purpose of Review Detrusor underactivity (DU) is a common but underrecognized contributor to lower urinary tract symptoms (LUTS), urinary retention, and impaired bladder emptying. Despite its prevalence, progress in DU research and clinical care has been hindered by ambi...
- Health & Medicine
Abstract Procedural sedation is essential for pediatric burn care, yet standardized, evidence-based regimens are lacking. This study characterizes the safety profile and pharmacological predictors of adverse events (AEs) in intensivist-led pediatric burn sedations. We conducted a...
- Health & MedicineOpen access
Differential regulation of basal and interferon-induced APOL1 gene expression in podocytes
APOL1 genetic variants associated with kidney disease become pathogenic when APOL1 gene expression is induced to high levels, however, the mechanism of APOL1 gene regulation is not well characterized. Using human podocyte cell lines, the induction of APOL1 gene expression from va...
- BiologyOpen access
Cohesin prevents local mixing of condensed euchromatic domains in living human cells
The human genome is folded into chromatin loops by the cohesin complex, forming functional chromatin domains that underlie transcription and DNA replication/repair. However, how cohesin organizes these domains in living cells, especially in active euchromatin, remains elusive. To...
- Health & Medicine
Poorly differentiated thyroid carcinoma (PDTC) and differentiated high-grade thyroid carcinoma (DHGTC) are uncommon thyroid malignancies, recently (re)codified into distinct entities with overlapping clinical significance. Recognizing them may be challenging for the general pract...
- Health & MedicineOpen access
ABSTRACT Human cytomegalovirus (HCMV) is a β-herpesvirus that is ubiquitous in the human population. HCMV has the largest genome of the human herpesviruses and encodes an array of genes that affect pathogenesis in different cell types. Given the ability of HCMV to replicate in a...
- BiologyOpen access
Abstract Age-associated remodeling of membrane lipid composition has been implicated in cellular dysfunction, yet the mechanisms linking lipid changes to membrane integrity and disease remain poorly defined. In the retinal pigment epithelium (RPE), lipid dysregulation is strongly...
- Health & Medicine
AI in the Exam Room: Its Potential to Transform the Healing Relationship in Rheumatology and Beyond
Data S1: Disclosureform Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
- BiologyOpen access
The beginning of the end for manual chart review: LLM-mediated database construction
Manual clinical data abstraction is the reference standard for research databases but is labor-intensive, costly, and susceptible to human error. We evaluated the accuracy of a locally deployed open-source large language model (LLM) framework for automated extraction of structure...
- Health & MedicineOpen access
Hypertension in chronic kidney disease (CKD) is frequently resistant to pharmacologic therapy, with sympathetic overactivity contributing to both elevated blood pressure (BP) and renal disease progression. Renal denervation (RDN) targets renal sympathetic nerves and may provide d...
- BiologyOpen access
Transient gamma events delineate somatosensory modality in S1
Gamma band activity localized to the primary somatosensory cortex (S1) in humans and animals is implicated in the higher order neural processing of painful and tactile stimuli. However, it is unclear if gamma band activity differs between these distinct somatosensory modalities....