Cleveland Clinic Akron General

LDL-C vs Lp(a): What We Know, the “Zero-LDL” Hypothesis, and Where We Stand in the PCSK9 Era

Despite significant breakthroughs in preventative medicine, atherosclerotic cardiovascular disease (ASCVD) is still the primary cause of morbidity and death worldwide. In this context, 2 apoB-containing particles-LDL and lipoprotein(a) [Lp(a)] have emerged as important but mechan...

Association between chiropractic spinal manipulation and adverse vascular events of the head and neck: systematic review and meta-analysis

Abstract Background Observational studies have raised concerns about a potential association between chiropractic spinal manipulation (CSM) and craniocervical vascular events (CCVE), including cervical artery dissection and stroke. We tested the null hypothesis of no significant...

Study protocol for first national vasa previa perinatal registry

Vasa previa is a rare but potentially catastrophic obstetric condition characterized by unprotected fetal blood vessels over or adjacent to the internal cervical os. Although advances in prenatal ultrasound have dramatically improved neonatal survival through planned cesarean del...

Biomarkers in Irritable Bowel Syndrome: Bridging Gut–Brain Mechanisms to Precision Care

Abstract Purpose of Review Irritable bowel syndrome is a common disorder of gut-brain interaction characterized by chronic abdominal pain and altered bowel habits in the absence of structural pathology. Its pathophysiology reflects a complex interplay between the central nervous...

An epidemiological assessment of hemodialysis, continuous kidney replacement therapy, and peritoneal dialysis in pediatric acute kidney injury patients

INTRODUCTION: Hemodialysis (HD), peritoneal dialysis (PD), and continuous kidney replacement therapy (CKRT) are major modalities of kidney replacement therapy (KRT) in pediatric acute kidney injury (AKI). This study uses TriNetX data to identify clinical characteristics of pediat...