Clermont Université

Osteocalcin and impaired cerebral resting-state functional connectivity in postmenopausal osteoporosis: a pilot case-control study

PURPOSE: Postmenopausal osteoporosis and circulating osteocalcin have been suggested to influence brain function. Objectives aim to explore associations between brain network resting-state functional magnetic resonance imaging (fMRI) connectivity, bone status, and circulating ost...

Experimental impact study on a micro-grid project in rural Madagascar: The Café Lumière project

This paper evaluates the impact of a pilot innovative project aiming at promoting a replicable model to create access to distributed electricity in rural areas where grid extension is economically infeasible. The project proposes building solar-powered micro-grids to provide affo...

Faithful Universal Graphs for Minor-Closed Classes

Abstract. It was proved by Huynh et al. [ Universality in Minor-Closed Graph Classes, preprint, arXiv:2109.00327, 2021] that any countable graph containing every countable planar graph as a subgraph has an infinite clique minor. We prove a finite, quantitative version of this res...

SEMIINFINITE SHEAVES ON AFFINE FLAG VARIETIES

Abstract We study a category of semiinfinite sheaves on the affine flag variety of a connected reductive algebraic group G , with coefficients in a field k $\Bbbk $ double struck k (of arbitrary characteristic different from that of the base field), generalizing some results of G...

Synthesis of Antiproliferative N-Chalconyl Imidazolidones and Mechanistic Evaluation of Prototype N-CIMZ 1 as a Macrophage-Modulating Antimitotic Agent

Background/Objectives: To address current aggressive breast cancer challenges, a novel series of eight N-chalconyl imidazolidone derivatives (N-CIMZs 1–8) was synthesized and evaluated for direct cytotoxicity and immunomodulation via macrophage polarization. Methods: Following an...

The Role of In Vitro Model Complexity in Lipid-Based Formulation Screening: A Case Study with Ticagrelor

Abstract Lipid-based formulations (LBFs) offer a promising strategy to enhance the oral bioavailability of poorly water-soluble drugs, such as biopharmaceutical classification system (BCS) Class IV compounds. However, their in vitro characterization remains challenging because of...

Low intensity transcranial electrical stimulation for schizophrenia: a triple-blind, randomized, sham-controlled multicenter trial (STIM’Zo)

Persistent symptoms in schizophrenia remain a major therapeutic challenge. Noninvasive electrical stimulation such as transcranial random noise stimulation (tRNS) may alleviate auditory hallucinations and negative symptoms, although existing evidence is limited to case reports an...

International Protocol for the Study of Amorphous Charred Objects in Archaeology (IPSACO 1.0)

Abstract Archaeobotanists around the world increasingly recognise that, alongside commonly studied materials such as seeds, fruits, wood charcoal, and chaff, archaeobotanical samples also contain fragments of carbonised organic (and sometimes inorganic) matter that vary in shape...

Tight (Double) Exponential Bounds for Identification Problems: Locating-Dominating Set and Test Cover

Abstract. We investigate fine-grained algorithmic aspects for classical identification problems in graphs, namely, Locating-Dominating Set, and in set systems, namely, Test Cover. In the first problem, an input is a graph [Formula: see text] on [Formula: see text] vertices and an...

Sensory plasticity of dorsal horn silent neurons as a critical mechanism for neuropathic pain

The spinal cord dorsal horn (DH) integrates sensory processing but undergoes critical plasticity following nerve injury, leading to mechanical allodynia, or “touch-evoked pain”. It has been proposed that after nerve injury, innocuous sensory neurons gain access to nociceptive-spe...

Perceived time in the presence of others: Further arguments for an attentional view of social facilitation

Although the effects of the presence of others on behavior constitute one of the oldest topics studied in social psychology, the reason why these effects occur is still the subject of scientific debate. Three hypotheses are commonly cited: (1) the presence of others facilitates d...

Proprioception drives tension wood formation for autotropic straightening and postural control in trees

Postural control in plant shoots relies on gravi- and photo- tropisms, driven by angular sensing and actuated by differential growth or reaction wood formation (tension wood in dicots). Control theory and kinematical models predict that posture stabilization additionally requires...

Oral health and systemic health outcomes: A call for interdisciplinary action

Abstract Objectives To make the case, from periodontology and dental public health, for interdisciplinary action on oral and systemic health, and to set out recommendations for practice, policy, education, and research. Materials and Methods A joint working group of the European...

An N-terminal CDC42 T43I variant reveals the mechanism of pyrin inflammasome activation

Heterozygous carboxyl-terminal variants in the RHO guanosine triphosphatase (GTPase) CDC42 are known to cause severe autoinflammatory syndromes. Here, we identified a heterozygous amino-terminal p.T43I (Thr 43 →Ile) CDC42 variant in patients with autoinflammation and uncovered a...