Clatterbridge Cancer Centre NHS Foundation Trust

69 Review of outcomes at a tertiary cancer centre of procarbazine (third line) and etoposide (fourth line) chemotherapy for recurrent gliomas

Abstract Introduction There is no standard recommended third- or fourth-line chemotherapy treatment for patients with recurrent gliomas. At our tertiary cancer centre, CCNU, procarbazine and etoposide are commonly used sequentially as second-, third- and fourth-line treatments. T...

44 UK radiotherapy practice in volume delineation–data from the APPROACH trial (ISRCTN:1339049) radiotherapy quality assurance (RTQA) programme benchmark outlining case

Abstract Introduction Interobserver variation in radiotherapy contouring can affect protocol compliance and the robustness of clinical trial outcomes. The APPROACH (Analysis of Proton vs Photon Radiotherapy in Oligodendroglioma and Assessments of Cognitive Health) trial protocol...

66 Case report: successful targeted treatments in NTRK fusion and BRAFV600E mutant gliomas

Abstract Introduction It is rare to find targetable mutations in gliomas. The evidence for using targeted agents remains limited. NICE recommends performing Next Generation and Whole Genome Sequencing (NGS, WGS) for all patients with brain tumours, to identify targets for treatme...