Civil Hospital Karachi

Hepatitis E vaccination in women of childbearing age: safety and tolerability outcomes

Abstract Background and objective Hepatitis E virus is a major cause of acute viral hepatitis and is endemic in Pakistan, where it contributes substantially to morbidity and mortality among women of childbearing age. The Hecolin vaccine is a potentially useful preventive measure,...

Comparative Effectiveness of Surgical and Non-Surgical Management of Pediatric Femoral Shaft Fractures: MetaAnalysis of Radiological Outcomes and Complications

ABSTRACT: Pediatric femoral shaft fractures can be managed using both surgical and non-surgical strategies, with treatment selection influenced by age, body weight, fracture stability, and associated injuries. This systematic review and meta-analysis aim to compare radiological,...

Comparative Effectiveness of Surgical and Non-Surgical Management of Pediatric Femoral Shaft Fractures: MetaAnalysis of Radiological Outcomes and Complications

ABSTRACT: Pediatric femoral shaft fractures can be managed using both surgical and non-surgical strategies, with treatment selection influenced by age, body weight, fracture stability, and associated injuries. This systematic review and meta-analysis aim to compare radiological,...

Efficacy and Safety of Baxdrostat in Hypertension: A GRADE-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials

BACKGROUND: Baxdrostat, a selective aldosterone synthase inhibitor, has emerged as a novel therapy for uncontrolled or resistant hypertension; however, randomized controlled trials (RCTs) have shown variable results. OBJECTIVE: To evaluate the efficacy and safety of baxdrostat co...