Civil Hospital Karachi

Safety and efficacy of evobrutinib in relapsing multiple sclerosis: a GRADE-assessed systematic review and meta-analysis

Background Bruton’s tyrosine kinase (BTK) inhibitors are emerging as a potential therapy for multiple sclerosis (MS) by targeting both peripheral and central nervous system–compartmentalized inflammation. Evobrutinib is the first BTK inhibitor evaluated in randomized controlled t...

Real-world safety and effectiveness of empagliflozin (Diampa®) alone or in combination with metformin (Diampa-M®) in patients with type 2 diabetes mellitus in Pakistan: a multicenter observational study

Abstract Background Type 2 diabetes mellitus (T2DM) is a growing public health challenge in Pakistan, where poor glycemic control is common. Sodium–glucose co-transporter 2 (SGLT2) inhibitors, such as empagliflozin, have shown glycemic, cardiovascular, and renal benefits in contr...

Cutaneous Tuberculosis in a 22-Day-Old Neonate:A Diagnostic Challenge and Case Report.

BACKGROUND: Cutaneous tuberculosis (CTB) is a rare extrapulmonary manifestation of tuberculosis, particularly in neonates. Its diagnosis is often challenging due to non-specific presentations that can mimic common conditions. CLINICAL DESCRIPTION: We report the case of a 22-day-o...

Hepatitis E vaccination in women of childbearing age: safety and tolerability outcomes

Abstract Background and objective Hepatitis E virus is a major cause of acute viral hepatitis and is endemic in Pakistan, where it contributes substantially to morbidity and mortality among women of childbearing age. The Hecolin vaccine is a potentially useful preventive measure,...

Comparative Effectiveness of Surgical and Non-Surgical Management of Pediatric Femoral Shaft Fractures: MetaAnalysis of Radiological Outcomes and Complications

ABSTRACT: Pediatric femoral shaft fractures can be managed using both surgical and non-surgical strategies, with treatment selection influenced by age, body weight, fracture stability, and associated injuries. This systematic review and meta-analysis aim to compare radiological,...

Comparative Effectiveness of Surgical and Non-Surgical Management of Pediatric Femoral Shaft Fractures: MetaAnalysis of Radiological Outcomes and Complications

ABSTRACT: Pediatric femoral shaft fractures can be managed using both surgical and non-surgical strategies, with treatment selection influenced by age, body weight, fracture stability, and associated injuries. This systematic review and meta-analysis aim to compare radiological,...

Efficacy and Safety of Baxdrostat in Hypertension: A GRADE-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials

BACKGROUND: Baxdrostat, a selective aldosterone synthase inhibitor, has emerged as a novel therapy for uncontrolled or resistant hypertension; however, randomized controlled trials (RCTs) have shown variable results. OBJECTIVE: To evaluate the efficacy and safety of baxdrostat co...