Chuo University

Reduced Detection of Human Orphan Gene Transcripts in Disease Tissue Relative to Expression- and Detection- Matched Controls

Human orphan genes are poorly annotated and lowly expressed, which makes their behavior in disease difficult to establish. We analyzed paired normal and disease RNA-seq libraries from four cohorts, quantified against a combined reference in which 2190 of 198,507 transcripts are o...

Transplanting a socio-cultural innovation: Life insurance in Meiji Japan

This study examines the establishment of a domestic life insurance industry in Meiji Japan from a comparative perspective. Life insurance represented a socio-cultural innovation that emerged in the context of Western modernization. Its rapid adaptation to Japan’s socio-economic a...

Exact SDP Relaxations for a Class of Quadratic Programs with Finite and Infinite Quadratic Constraints

Abstract. We investigate exact semidefinite programming (SDP) relaxations for the problem of minimizing a nonconvex quadratic objective function over a feasible region defined by both finitely and infinitely many nonconvex quadratic inequality constraints (semi-infinite QCQPs). S...

Identities and inequalities for integral transforms involving squares of the Bessel functions

We consider an integral transform given by Tνf(s):=π∫0∞rsJν(rs)2f(r) dr, where Jν denotes the Bessel function of the first kind of order ν. As shown by Walther (2002), this transform plays an essential role in the study of optimal constants of smoothing estimates for the free Sch...

Tsunami excitation by localized subsidence associated with crater formation: a numerical case study for the October 2023 Sofu Seamount event

Abstract The October 2023 tsunami from Sofu Seamount showed large amplitudes relative to the associated seismic activity, suggesting atypical non-tectonic source processes. Comparisons of pre- and post-event bathymetric data revealed substantial topographic changes at Sofu Seamou...

Network impact assessment and stability enhancement through Markov chain analysis and load balancing

Abstract This study proposes a methodology for analyzing and improving network stability using discrete Markov chains. By modeling device transitions in network logs as Markov chains, we developed two models: a Network Impact Assessment Model and a Network Stability Optimization...

Bridging the Gap in Tsunami Runup Observations under Rough Sea States: High-Frequency Automated Image Analysis during the 2025 Kamchatka Event

Abstract Following the 2025 Kamchatka Earthquake (Mw 8.8), tsunamis were observed along the Pacific coast of Japan, as well as in many other coastal regions. This study applies an automated image analysis method to video footage from the Hasaki Oceanographical Research Station to...

Integrating Meta‐Analysis Into a Specific Study (InMASS) for Estimating the Target‐Population Average Treatment Effect

Randomized controlled trials remain the benchmark for estimating treatment effects, yet practical constraints often restrict sample sizes in a prespecified target population. In such settings, evidence from completed trials is frequently available only in aggregate form, which pr...

Tongue variability increases in second-language Lombard speech

Speech uttered in the native language (L1) in noise might be acoustically changed in terms of prosodic features as well as segmental ones. This phenomenon is known as the Lombard effect. Recent studies have indicated that the Lombard effect might also occur in the speaker’s secon...

Modeling user redemption behavior in complex digital incentive environment: an empirical study using large-scale transactional data

Abstract The digital economy implements complex incentive systems to retain users through point redemption. Understanding user behavior in such complex incentive structures presents a fundamental challenge, especially in estimating the value of these digital assets against tradit...

Polyhedral Clinching Auctions with a Single Sample

We address auctions in two-sided markets with budget-constrained buyers, a fundamental setting with important applications such as display advertising. Our goal is to design efficient mechanisms that satisfy dominant-strategy incentive compatibility, individual rationality, and b...

Interpretable integration of CITE-seq RNA and ADT profiles without explicit modality-weight tuning via tensor decomposition-based unsupervised feature extraction

CITE-seq jointly profiles cellular transcripts and surface proteins, but RNA and ADT modalities differ markedly in dimensionality, sparsity, and noise characteristics. We applied tensor-decomposition-based unsupervised feature extraction to paired CITE-seq data by constructing a...

Black-Box Construction of Partial Key Exposure Resilient Symmetric-Key Encryption Scheme

In a TLS session, the user is granted access solely to the encryption and decryption oracles, <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mi>ℰ</mml:mi> <mml:mo stretchy="false">(</mml:mo> <mml:mi>K</mml:mi> <mml:mo>,</mml:mo> <mml:mi>·</mml:mi> <mml:...

The association of corporate measures and health management initiatives with employee engagement in Japanese companies

Using data from 2,502 companies in Japan’s Health and Productivity Management Survey, this study examined determinants of employee engagement and corporate success. Regression analysis showed that hourly paid leave (adjusted odds ratio [aOR]: 1.29, 95% CI: 1.07–1.56) and communic...

Trade-off between repository footprint and radiotoxicity in geological disposal of vitrified high-level waste from spent MOX fuels: quantitative assessment of simplified minor actinide separation

Radioactive waste management remains a critical challenge for the sustainability of nuclear energy systems, particularly for closed fuel cycles utilizing mixed oxide (MOX) fuel. MOX fuel contains significantly higher concentrations of minor actinides (MAs) and heat-generating nuc...