Chungnam National University Hospital

Non-Invasive Brain Stimulation for Central Neuropathic Pain: An Exploratory Randomized Sham-Controlled Crossover Trial

Background/Objectives: Central neuropathic pain (CNP) is difficult to manage, and comparative evidence for non-invasive brain stimulation is limited. We explored the short-term efficacy and safety of repetitive transcranial magnetic stimulation (rTMS) and transcranial direct curr...

Lipid Burden and Efficacy of Preventive PCI of Vulnerable Atherosclerotic Coronary Plaques: Post Hoc Analysis From the PREVENT Trial

BACKGROUND: Preventive percutaneous coronary intervention (PCI) of non–flow-limiting lesions (fractional flow reserve >0.80) that are high-risk plaques has emerged as a potential strategy to reduce cardiac events. However, identifying which lesions derive the greatest benefit fro...

Trastuzumab plus nivolumab with gemcitabine and cisplatin as first-line therapy for HER2-positive unresectable biliary tract cancer: a phase 1b/2 trial

Biliary tract cancers (BTCs) are associated with poor outcomes despite recent incorporation of immune checkpoint inhibitors into first-line chemotherapy. Human epidermal growth factor receptor 2 (HER2) overexpression or amplification defines a therapeutically targetable subset of...

Arthroscopic partial meniscectomy should be performed carefully for medial meniscus tear with the anteromedial meniscofemoral ligament

The clinical relevance of the anteromedial meniscofemoral ligament (AMMFL) in medial meniscus (MM) tears remains unclear. This study investigated whether arthroscopic partial meniscectomy (APM) for MM tears with AMMFL is associated with joint degeneration. Among 2568 patients who...

Extended treatment duration and recurrence in successfully treated drug-susceptible pulmonary tuberculosis with cavity on chest radiograph

Background Cavity on chest radiograph is recognized as an independent risk factor for recurrence in pulmonary tuberculosis (TB), but evidence supporting extended treatment in these patients remains limited, particularly in real-world data from Korea. Methods We performed a retros...

Serial Changes in CSF Volume Proportion on Brain CT and 6-Month Neurologic Outcomes After Cardiac Arrest: A 72–96-h Landmark Cohort Study

Background: Single-time-point cerebrospinal fluid (CSF) volume proportion (pCSFV) has shown limited prognostic utility after out-of-hospital cardiac arrest (OHCA). We hypothesized that serial within-patient change in pCSFV (ΔpCSFV), rather than absolute values, would reflect prog...

Predictors of Early Versus Late Atrial Tachyarrhythmia Recurrence After Cryoballoon Ablation by Atrial Fibrillation Type

ABSTRACT Introduction Patient characteristics and predictors of early (ERAT) and late (LRAT) recurrence of atrial tachyarrhythmia by atrial fibrillation (AF) type after cryoballoon ablation (CBA) remain poorly defined. Methods Using the Korean Heart Rhythm Cryoballoon Registry (1...

Towards a universal ovarian cancer biomarker model: clinical validation of Trx1 and CA125 dual strategy

Abstract Background Ovarian cancer is the fifth leading cause of cancer-related mortality in women, with early detection being critical for improving patient outcomes. Current diagnostic biomarkers, including Cancer antigen 125 (CA125), human epididymis protein 4 (HE4), and their...

Paired Whole-Genome Sequencing of Scalp Angiosarcoma and Matched Lung Metastasis Reveals Common Clonal Origin and Lung-Specific Evolution

Background and Clinical Significance: Cutaneous angiosarcoma frequently metastasizes to the lungs, where it may rarely present as diffuse cystic lung disease with recurrent pneumothorax, resulting in substantial diagnostic difficulty. We report a case of pulmonary metastatic cuta...

Korean Clinical Practice Guidelines for Rehabilitation in Critically Ill Patients and Post-Intensive Care Syndrome

Background: Survivors of critical illness commonly experience persistent physical, cognitive, and psychological impairments, collectively known as post–intensive care syndrome. Although intensive care unit (ICU) rehabilitation is now recognized as an important part of recovery af...

Incidental Removal of an Aspirated Tooth During Routine Endotracheal Suctioning: A Case Report

Background/Objectives: Foreign body aspiration is a potentially life-threatening emergency that commonly requires bronchoscopic removal. Dental aspiration in elderly patients may occur following trauma, seizures, or altered mental status and can lead to airway obstruction and res...

Vitamin B deficiency and sarcopenia: an integrated narrative review of metabolic, inflammatory, endoplasmic reticulum stress, and myokine signaling pathways

Sarcopenia is an age-related skeletal muscle disorder characterized by progressive decline in muscle mass, strength, and physical performance, leading to frailty, disability, falls, and increased mortality. Although its pathogenesis is multifactorial, growing evidence indicates t...

Nutritional support for critically ill patients by the Korean Society for Parenteral and Enteral Nutrition—part II: a clinical practice guideline

Purpose: Nutritional therapy is an essential component of intensive care management. Appropriate nutritional support may reduce infectious and metabolic complications and promote recovery in critically ill patients. However, nutritional practices vary across institutions, and int...