Chung Shan Medical University Hospital

Development of a clinical prediction model for parenteral nutrition-associated cholestasis in preterm infants: a retrospective cohort study

Abstract Background Parenteral nutrition-associated cholestasis (PNAC) remains a severe and potentially life-threatening complication in preterm infants requiring extended parenteral nutrition. This study aimed to identify independent risk factors for PNAC and develop a robust pr...

Chinese herbal medicine therapy reduces all-cause and cardiovascular disease-related mortalities in acquired hemolytic anemia: A Taiwanese nationwide retrospective cohort study

Objectives To assess whether Chinese herbal medicine (CHM) treatment was associated with all-cause and cardiovascular disease (CVD)-related mortality in Taiwanese patients with acquired hemolytic anemia (AHA). Design & setting This population-based retrospective cohort analysis u...

Fucoidan from Fucus Vesiculosus Alleviates Interstitial Cystitis by Suppressing the AKT/NLRP3 Inflammasome Axis

Background/Objectives: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic inflammatory bladder disorder that lacks an effective treatment agent. Fucoidan (FUC), isolated from Fucus vesiculosus, is a sulfated polysaccharide that exhibits potent anti-inflammatory and...

Opportunistic Coronary Artery Calcium Reporting on Non‐Gated Chest CT : From Detection to Clinical Action

Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

Effectiveness of a PowerPoint-based rapid decision support system in ACLS refresher training: A randomized trial

A PowerPoint-based rapid decision support system (RDSS) was evaluated as a low-resource adjunct to standard Advanced Cardiac Life Support (ACLS) refresher training in a single-center randomized trial involving 40 postgraduate year-2 (PGY-2) physicians. Participants were assigned...

Dietary‐Derived Corchorus olitorius L. Extract Suppresses KRAS‐Mutant Pancreatic Cancer by Activating Ferritinophagy‐Dependent Ferroptosis

ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by frequent activating mutations in the Kirsten rat sarcoma viral oncogene homologue (KRAS) and limited therapeutic options. Corchorus olitorius L., a traditional edible plant widely...

Association Between Bladder Management Strategies and Symptomatic Urinary Tract Infections in Patients with Chronic Spinal Cord Injury: Lessons from a 5-Year Longitudinal Cohort

Background: Urinary tract infections (UTIs) are a leading cause of morbidity in patients with chronic spinal cord injury (SCI). This study examined the incidence of first and recurrent symptomatic UTIs in patients with chronic SCI and explored clinical factors associated with inf...

Localized Topical Melatonin Therapy Promotes Hair Regrowth in C57BL/6 Mice in Association with Wnt/β-Catenin Pathway Activation

Melatonin, a methoxyindole synthesized by the pineal gland, is secreted in response to photoperiodic cues relayed from the retina through an endogenous circadian oscillator within the suprachiasmatic nucleus. Consequently, melatonin secretion regulates the circadian rhythm. Melat...

Reorganization of motor unit discharge-state space during ischemia-assisted fatigue: an energy landscape analysis

Neuromuscular fatigue increases variability in motor-unit (MU) discharge and force output, yet how it reorganizes population-level MU discharge dynamics remains poorly understood. Conventional analytical approaches primarily quantify discharge magnitude, variability, and common s...

Long-Term Corticosteroid-Induced Ocular Hypertension Model Produced by Topical Rinderon-A Ointment Application

Adverse effects associated with prolonged corticosteroid therapy are strongly associated with increased intraocular pressure (IOP), which may progress to iatrogenic glaucoma and irreversible blindness if left untreated. Developing reliable animal models is essential for investiga...

Urinary Antimony as a Biomarker for Differentiating Heroin and Brown Mixture Use

Heroin is classified as a Schedule I controlled substance with severe legal consequences for its use, whereas liquid Brown Mixture (BM) is a legally available and commonly prescribed cough remedy in Taiwan. However, numerous cases of BM ingestion have been misinterpreted as heroi...

Simulation-based ultrasound-guided lumbar puncture training using a flipped classroom: a single-arm pilot programme evaluation

Abstract Background Traditional landmark-guided lumbar puncture (LP) has high failure rates among novice emergency medicine (EM) clinicians. While ultrasound guidance improves success, structured training models remain limited and expensive. We evaluated a cost-effective, simulat...