Chung Shan Medical University

Development of a clinical prediction model for parenteral nutrition-associated cholestasis in preterm infants: a retrospective cohort study

Abstract Background Parenteral nutrition-associated cholestasis (PNAC) remains a severe and potentially life-threatening complication in preterm infants requiring extended parenteral nutrition. This study aimed to identify independent risk factors for PNAC and develop a robust pr...

Cross-cultural adaptation and validation of the Traditional Chinese NASA Task Load Index (NASA-TLX) for assessing perceived workload in Taiwanese adults

Background Perceived workload is central to occupational health, ergonomics, and rehabilitation research, yet no guideline-based Traditional Chinese version of the NASA Task Load Index (NASA-TLX) has been available for Taiwan and other Traditional-Chinese-speaking settings. Objec...

Microscope-Integrated Augmented Reality-Assisted Navigation for C1–C2 Instrumentation: A Retrospective Single-Center Case Series

Objective: Posterior C1–C2 instrumentation is technically demanding because of the complex osseous and vascular anatomy of the atlantoaxial region. This retrospective single-center case series aimed to describe the technical feasibility and observed screw-placement outcomes of a...

Treatment-Free Interval as a Prognostic Factor for Survival Outcomes in Patients with Advanced or Recurrent Endometrial Cancer Treated with Pembrolizumab Plus Lenvatinib: A Multi-Institutional Real-World Cohort Study

Background/Objectives: The treatment-free interval (TFI) predicts benefit from platinum rechallenge in gynecological cancers, but its prognostic value in patients receiving second-line pembrolizumab plus lenvatinib for recurrent endometrial cancer (EC) is unknown. We evaluated wh...

Chinese herbal medicine therapy reduces all-cause and cardiovascular disease-related mortalities in acquired hemolytic anemia: A Taiwanese nationwide retrospective cohort study

Objectives To assess whether Chinese herbal medicine (CHM) treatment was associated with all-cause and cardiovascular disease (CVD)-related mortality in Taiwanese patients with acquired hemolytic anemia (AHA). Design & setting This population-based retrospective cohort analysis u...

Claudin 18 is not a biomarker for breast mucinous tumor

BACKGROUND: Breast mucinous cystadenocarcinoma (BMCA) is an exceptionally rare malignancy that may resemble mucinous neoplasms of the pancreas, ovary, lung and colorectum. Claudin 18 (CLDN18), particularly its gastric-associated isoform CLDN18.2, is an emerging therapeutic target...

Fucoidan from Fucus Vesiculosus Alleviates Interstitial Cystitis by Suppressing the AKT/NLRP3 Inflammasome Axis

Background/Objectives: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic inflammatory bladder disorder that lacks an effective treatment agent. Fucoidan (FUC), isolated from Fucus vesiculosus, is a sulfated polysaccharide that exhibits potent anti-inflammatory and...

Erinacine C Attenuates Alzheimer’s-like Pathology: A Study in APP/PS1 Mice and PC12 Cells

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-beta (Aβ) deposition and cognitive decline. Clinical evidence indicates that Hericium erinaceus whole fruiting body powder offers limited therapeutic efficacy, which is suggested to be c...

Beyond Caregiving: Recovery and Growth Among Primary Caregivers Following the Loss of a Family Member Living With Dementia

BACKGROUND: Caring for a family member with dementia places long-term emotional, physical, and social strain on primary caregivers. Although extensive research has examined the caregiving phase, relatively few studies have explored caregivers' recovery experiences following berea...

Effectiveness of a PowerPoint-based rapid decision support system in ACLS refresher training: A randomized trial

A PowerPoint-based rapid decision support system (RDSS) was evaluated as a low-resource adjunct to standard Advanced Cardiac Life Support (ACLS) refresher training in a single-center randomized trial involving 40 postgraduate year-2 (PGY-2) physicians. Participants were assigned...

Dietary‐Derived Corchorus olitorius L. Extract Suppresses KRAS‐Mutant Pancreatic Cancer by Activating Ferritinophagy‐Dependent Ferroptosis

ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by frequent activating mutations in the Kirsten rat sarcoma viral oncogene homologue (KRAS) and limited therapeutic options. Corchorus olitorius L., a traditional edible plant widely...

Association Between Bladder Management Strategies and Symptomatic Urinary Tract Infections in Patients with Chronic Spinal Cord Injury: Lessons from a 5-Year Longitudinal Cohort

Background: Urinary tract infections (UTIs) are a leading cause of morbidity in patients with chronic spinal cord injury (SCI). This study examined the incidence of first and recurrent symptomatic UTIs in patients with chronic SCI and explored clinical factors associated with inf...

Localized Topical Melatonin Therapy Promotes Hair Regrowth in C57BL/6 Mice in Association with Wnt/β-Catenin Pathway Activation

Melatonin, a methoxyindole synthesized by the pineal gland, is secreted in response to photoperiodic cues relayed from the retina through an endogenous circadian oscillator within the suprachiasmatic nucleus. Consequently, melatonin secretion regulates the circadian rhythm. Melat...

Reorganization of motor unit discharge-state space during ischemia-assisted fatigue: an energy landscape analysis

Neuromuscular fatigue increases variability in motor-unit (MU) discharge and force output, yet how it reorganizes population-level MU discharge dynamics remains poorly understood. Conventional analytical approaches primarily quantify discharge magnitude, variability, and common s...

Long-Term Corticosteroid-Induced Ocular Hypertension Model Produced by Topical Rinderon-A Ointment Application

Adverse effects associated with prolonged corticosteroid therapy are strongly associated with increased intraocular pressure (IOP), which may progress to iatrogenic glaucoma and irreversible blindness if left untreated. Developing reliable animal models is essential for investiga...

Urinary Antimony as a Biomarker for Differentiating Heroin and Brown Mixture Use

Heroin is classified as a Schedule I controlled substance with severe legal consequences for its use, whereas liquid Brown Mixture (BM) is a legally available and commonly prescribed cough remedy in Taiwan. However, numerous cases of BM ingestion have been misinterpreted as heroi...

Simulation-based ultrasound-guided lumbar puncture training using a flipped classroom: a single-arm pilot programme evaluation

Abstract Background Traditional landmark-guided lumbar puncture (LP) has high failure rates among novice emergency medicine (EM) clinicians. While ultrasound guidance improves success, structured training models remain limited and expensive. We evaluated a cost-effective, simulat...