CHU Dijon Bourgogne

Impact of comedication on survival and toxicity in patients treated with systemic therapy for unresectable hepatocellular carcinoma

Introduction This study aims to evaluate the association between concomitant medication, survival and toxicity in patients with unresectable hepatocellular carcinoma (uHCC) treated with systemic therapy. Methods All uHCC patients treated with atezolizumab plus bevacizumab or durv...

Healthcare professionals’ views on expanding newborn screening with or without genomics in France: Results of the SeDeN-p2 study

Abstract Therapeutic advances and the rapid, cost-effective development of next-generation sequencing (NGS) have increased interest in expanding newborn screening (NBS) through genomics. The SeDeN-p2 study assessed the acceptability among healthcare professionals in France, of ex...

Relapsed/refractory WAldenström macroglobulinemia patients treated by VEnetoclax with or without anti-CD20 antibody: WAVE a retrospective study of the French CLL/WM group (FILO)

Abstract Recently venetoclax (Ven) monotherapy showed promising efficacy for relapsed/refractory (R/R) Waldenström macroglobulinemia (WM), a population with significant medical unmet need. We report the efficacy and safety of Ven associated or not with anti-CD20 therapy, in a rea...

Lithium chloride in vitro treatment shows potential to rescue the neuronal phenotype caused by WDFY3 haploinsufficiency

We provide a comprehensive phenotypic characterization of loss-of-function (LoF) variants in WDFY3 based on the largest cohort reported to date (n = 32). Our findings define a monogenic disorder marked by neuropsychiatric features (including autism and ADHD), mild to moderate neu...

Serum GFAP and Age Accurately Distinguish AQP4 ‐ IgG Positive and Double Seronegative NMOSD From MOGAD After a Recent Attack

BACKGROUND: Serum neurofilament-light chain (sNfL) and glial fibrillary acidic protein (sGFAP) are associated with multiple sclerosis (MS) activity. This study aimed to identify patient- and disease-level determinants of sNfL and sGFAP and to evaluate their ability to support dif...

Association of cryptic pregnancy and alcohol consumption with fetal alcohol spectrum disorder: a nationwide population-based study of 5 million women in 2015–2022

Cryptic pregnancy (CP) also known as pregnancy denial remains an underexplored risk factor for FASD. To our knowledge, there is no available epidemiologic data in the scientific literature exploring the association between CP and FASD. This study aimed to examine the association...

Win ratio analysis of surgical approaches for lung cancer: a nationwide observational study using the French national hospital discharge database

Minimally invasive surgical approaches have gained widespread adoption, yet comparative evidence integrating multiple hierarchical endpoints remains limited. Our objective was to compare the surgical approaches for lung cancer resection (thoracotomy, VATS, robot-assisted surgery)...