Christian Medical College, Vellore

Enhanced Functional Independence Score for Haemophilia (E‐FISH) for Early Detection of Musculoskeletal Changes

BACKGROUND: The functional independence score in haemophilia (FISH) is a widely used performance-based assessment tool designed to evaluate musculoskeletal function in children with haemophilia (CWH). Nevertheless, FISH exhibits a ceiling effect in children who are undergoing ear...

A Fast and Generalizable Deep Neural Network for the Detection of Atrial Fibrillation

Atrial fibrillation (AFib) is the most prevalent sustained cardiac arrhythmia, yet most deep learning detectors are validated on a single cohort and few report uncertainty. We developed a compact 14M-parameter convolutional neural network for binary AFib classification from 10 s,...

Estimation of Effective Dose Received by Caregivers During [ 18 F]FDG PET/CT Studies

Caregivers who assist patients during [18F]FDG PET/CT are exposed to ionizing radiation, particularly when close physical support is required. Limited real-world data are available about the actual doses received by caregivers during routine clinical practice. This study aimed to...

Timing of intraventricular hemorrhage in preterm infants less than 32 weeks of gestational age

OBJECTIVES: Intraventricular hemorrhage (IVH) remains a major challenge in preterm infants, with its exact timing and periods of greatest risk still debated. This study aims to describe the timing, incidence, severity, and risk factors for IVH in preterm infants born before 32 we...

Trajectory of functional recovery and health-related quality of life following multilevel soft-tissue surgery in children with spastic diplegic cerebral palsy: a prospective longitudinal observational study

This prospective longitudinal observational study characterized 3-year functional mobility and health-related quality-of-life trajectories following single-event multilevel soft-tissue surgery in 32 children with spastic diplegic cerebral palsy, Gross Motor Function Classificatio...

Consensus recommendations for standardising ILD multidisciplinary discussions in India

Abstract Background Interstitial lung diseases (ILDs) are complex, heterogeneous disorders that require accurate diagnosis and coordinated care. Multidisciplinary discussions (MDMs) are considered the gold standard for ILD management; however, in India, the implementation of stru...

Encoder-controlled functional electrical stimulator for stroke rehabilitation: a usability study

Numerous therapeutic interventions have been explored for stroke related dysfunctions with various degrees of success; however, rehabilitation of the stroke-affected upper limb and hand still remains a challenge. Focus has now shifted to rehabilitative training devices that augme...

Diagnostic accuracy of high-risk HPV DNA and cytology in diagnosing precancerous and early malignant cervical lesions: a protocol for a systematic review and meta-analysis

Persistent infection with high-risk hr-HPV is a major cause in the aetiopathogenesis of cervical cancer. Early detection by screening is the best strategy for prevention. Two major screening techniques hr-HPV DNA and Pap smear, target the disease condition at two different timepo...

Disease progression in hidradenitis suppurativa: A multidimensional framework

Abstract Hidradenitis suppurativa (HS) is increasingly recognized as a progressive inflammatory disease in which recurrent follicular inflammation, tunnel formation and systemic inflammation drive cumulative, largely irreversible tissue damage, quality‐of‐life impairment and card...

Decadal changes in IgG seroprevalence of hepatitis A and E virus in Urban Vellore, India: Persistent Endemicity or Epidemiological Shift?

Hepatitis A virus (HAV) and hepatitis E virus (HEV) are major causes of acute viral hepatitis in low- and middle-income countries (LMIC) and are closely linked to sanitation, hygiene, and socio-economic conditions. Rapid urbanisation and improvements in water and sanitation infra...

Theory–simulation–application framework to enhance biostatistical capacity for HIV and cancer data analysis in sub-Saharan Africa: lessons learnt from Tanzania

Enhancing biostatistical capacity in sub-Saharan Africa (SSA) is imperative for the efficient analysis of routinely collected health data and for clinical and public health decision-making. We describe the experiences and lessons learnt from implementing advanced statistical capa...

Opioid-Sparing Versus Opioid-Based Analgesia for Craniotomy: A Multicenter Randomized Controlled Trial

Introduction: Pain control remains a challenge after neurosurgery. Opioid-sparing analgesia may provide better pain relief without opioid-related side effects after craniotomy. We aimed to compare analgesia requirement and postoperative pain between opioid-sparing and opioid-base...

Pan genome clustering identifies a novel mosaic prophage specific to Salmonella Enteritidis lineage associated with the invasive disease in India

Abstract Salmonella enterica serovar Enteritidis is a leading cause of bloodstream infections (BSIs), particularly in sub-Saharan Africa (sSA). While typhoidal salmonellosis is well documented in South Asia, the burden and genomic characteristics of non-typhoidal Salmonella (NTS)...

Technology and Obesity: A Year in Review

SMART technological advancements help diagnose, treat, and monitor various diseases at the earliest stages. It presents an opportunity to maintain the key components of conventional obesity management programming while reducing costs and provider time inputs. Various machine lear...

Optimizing adult pneumococcal vaccination in India: Evidence from serotype surveillance

Introduction: Pneumococcal disease, caused by Streptococcus pneumoniae , is a major public health burden with high morbidity and mortality across all age groups in India. Limited adult pneumococcal vaccination policies, evolving serotype patterns, and delayed herd protection from...

Prospective validation of a non-invasive bedside protocol for tracheostomy decannulation in acquired brain injury with otolaryngologic concordance

Decannulation of tracheostomy in individuals with acquired brain injury (ABI) is challenging and often requires endoscopic airway assessment. A reliable noninvasive bedside protocol could support decision-making in neurorehabilitation settings. We conducted a prospective observat...

Recent advances in the medical management of thyroid eye disease

Purpose of review Thyroid eye disease (TED) is a debilitating autoimmune disorder that can cause facial disfigurement, impair vision and reduce the quality of life. Novel insights into the pathogenesis of TED in the recent years have stimulated efforts to develop newer targeted m...

Patterns of Errors and Hallucinations Among ChatGPT, Perplexity, Qwen, and Copilot in Answering ACR DXIT Radiology Questions

Abstract Large language models (LLMs) are increasingly used in radiology workflows. In this study, we aimed to compare the performance and characteristics of errors made by ChatGPT, Perplexity, Qwen, and Microsoft Copilot using standardized radiology questions. This cross-platfor...

Diagnostic performance of a centrifugation-free stool processing kit in conjunction with Xpert®MTB/RIF Ultra for paediatric tuberculosis: a multicentre prospective study in five low and middle-income countries

Diagnosing paediatric tuberculosis (TB) remains challenging. Currently available diagnostic tests have limited accuracy, and most sampling methods are invasive. In 2021, the World Health Organisation (WHO) endorsed the use of molecular WHO-recommended rapid diagnostic tests (mWRD...

Environmental surveillance for Sabin polioviruses, Salmonella, and antimicrobial resistance genes in an urban setting in southern India

Sewage is the easiest place to find organisms that replicate in human or animal guts. Although World Health Organization (WHO) recommends the WHO 2-phase method for environmental surveillance of polioviruses, new methods such as the Bag Mediated Filtration System (BMFS) have been...