Chris O’Brien Lifehouse

Insulin‐Like Growth Factor Axis and Survival in Metastatic Hormone‐Sensitive Prostate Cancer: Post‐Hoc Analysis From the ENZAMET Phase 3 Trial

ABSTRACT Background A higher ratio of IGF‐1:IGF binding protein 1 (IGFBP1) was associated with improved prognosis in the CHAARTED trial of docetaxel in participants with metastatic hormone‐sensitive prostate cancer (mHSPC). The ENZAMET trial demonstrated the survival benefit of a...

Long‐Term Health‐Related Quality of Life After Jaw Reconstruction With Fibula Free Flaps Using Primary Endosseous Implants and Buried Skin Grafts to Facilitate Implant‐Retained Dental Prostheses

ABSTRACT Background Data on health‐related quality‐of‐life (HRQoL) is indispensable in understanding patient outcomes following jaw reconstruction. This study aims to evaluate long‐term HRQoL using validated patient‐reported outcome measures (PROMs) following jaw reconstruction u...

Implementation and Management of Cancer Clinical Quality Registries in Australia: A Qualitative Study

ABSTRACT Background In Australia, clinical quality registries (CQRs) for cancer care are becoming increasingly common, requiring integration across multiple sectors of the health system. This study sought to identify the means to successful implementation of CQRs in Australia by...

Level IA Nodal Involvement in Parotid Cutaneous Squamous Cell Carcinoma

ABSTRACT Background The frequency of Level IA metastasis in advanced cutaneous squamous cell carcinoma (cSCC) remains undefined yet determines the oncological safety of submental island flap (SIF) reconstruction. Methods A retrospective cohort study was performed on 131 adults wh...

Patient-Specific Sensitivity of Osteotomy Interface Modelling in Mandibular Reconstruction

This study systematically investigates the influence of different interface modelling assumptions on biomechanical predictions using patient-specific models and evaluates their agreement with postoperative configurations. Five mandibular reconstruction cases using vascularised os...

Current Evidence on Best Practice Dental Survivorship Care for People With Head and Neck Cancer: An Overview of Systematic Reviews and Emerging Evidence

INTRODUCTION: Head and neck cancer (HNC) survival is improving, increasing the need to address long-term survivorship issues. Dental survivorship-care before, during, and after treatment-remains inconsistent across services. We conducted a review of systematic reviews and emergin...