Chonnam National University Hwasun Hospital

Phase IIa Trial of Locoregional High-Dose Autologous Natural Killer Cell Therapy Combined with Hepatic Arterial Infusion Chemotherapy for Locally Advanced Hepatocellular Carcinoma

PurposeHepatocellular carcinoma (HCC) refractory to locoregional therapies remains a major clinical challenge.This study evaluated the efficacy and safety of locoregional high-dose autologous natural killer (NK) cell therapy combined with hepatic arterial infusion chemotherapy (H...

Automated CT-based quantification of knee osteophytes for robotic-assisted total knee arthroplasty: a multi-cohort study

Abstract Preoperative computed tomography (CT) is routinely acquired for planning robotic-assisted total knee arthroplasty (TKA), yet osteophyte burden is not quantitatively characterized. We developed automated CT-based osteophyte quantification and evaluated it against blinded...

Salivary Microbiota and Network Alterations in Oral Lichen Planus with Candida Compared to Healthy Controls

Background: Oral lichen planus (OLP) is a chronic immune-mediated mucosal disorder frequently accompanied by Candida colonization. However, the polymicrobial interactions and network alterations underlying this association remain poorly understood. This study aimed to characteriz...

TSH Stimulation Reveals Additional Bone Metastases on [18F]FDG PET/CT in Metastatic Follicular Thyroid Carcinoma

A 62-year-old woman with metastatic follicular thyroid carcinoma underwent 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) PET/CT before a second course of radioactive iodine therapy because of a markedly elevated serum thyroglobulin level (498.0 ng/mL). The initial PET/CT was perform...

Concomitant Anemia and Thrombocytopenia as Clinical Clues to Thrombotic Thrombocytopenic Purpura in Patients with Stroke or Stroke-Like Symptoms

pathic hemolytic anemia (MAHA), fever, thrombocytopenia, renal impairment, and neurological deficits [1].However, this full pentad is observed in only approximately 5 to 10% of patients, whereas thrombocytopenia and MAHA are present in most cases [2, 3].At our tertiary care hospi...

Trastuzumab plus nivolumab with gemcitabine and cisplatin as first-line therapy for HER2-positive unresectable biliary tract cancer: a phase 1b/2 trial

Biliary tract cancers (BTCs) are associated with poor outcomes despite recent incorporation of immune checkpoint inhibitors into first-line chemotherapy. Human epidermal growth factor receptor 2 (HER2) overexpression or amplification defines a therapeutically targetable subset of...

Robotic bronchial restapling after inadvertent stapling of an endobronchial suction tube: technical note and a prestapling time-out

Abstract Foreign body entrapment during bronchial stapling is rare but may result in severe airway injury. We report an unusual intraoperative complication during robot-assisted thoracic surgery (RATS) lobectomy: inadvertent stapling of an endobronchial suction tube into the righ...

Age- and sex-adjusted genomic differences between Korean and Beat AML cohorts

Genomic profiling plays a central role in risk stratification and therapeutic decision-making in acute myeloid leukemia (AML), yet the clinical implications of population-specific genomic architectures remain incompletely defined. We conducted a prospective, multicenter study of...

Circular RNA circSNRK regulates inflammatory processes and TXNIP expression by acting as a miR-128-3p sponge in age-related macular degeneration

Age-related macular degeneration (AMD) is an ocular disease that causes visual impairment in older individuals, primarily due to degeneration of the retinal pigment epithelium (RPE). In this progressive disease, damaged RPE cells release pro-inflammatory factors into the extracel...

Antibiotic Prophylaxis for Transrectal Prostate Biopsy

Transrectal prostate biopsy (TRPB) is widely used for the diagnosis of prostate cancer but carries a clinically meaningful risk of infectious complications due to inoculation and translocation of rectal flora into the urinary tract and bloodstream. Antibiotic prophylaxis remains...

Danburstotug, an anti‐ PD ‐ L1 antibody, in relapsed/refractory extra‐nodal natural killer/T‐cell lymphoma: The phase 2 DISTINKT study

Summary Relapsed/refractory extra‐nodal natural killer/T‐cell lymphoma (R/R ENKTL) has limited treatment options. Danburstotug, an antibody targeting programmed death‐ligand 1 (PD‐L1), was evaluated in adults with R/R ENKTL in a phase 2, open‐label study (NCT04414163). Danburstot...

Integrative Genomic Analysis Reveals Molecular and Clinical Disparities between Bladder and Upper Tract Urothelial Carcinoma in K-MASTER Program

Purpose: The clinical outcome of urothelial carcinoma presents significant variability, reflecting its molecular composition, epidemiologic attributes, and primary site of origin. Despite histological similarities, upper tract urothelial carcinoma (UTUC) and bladder urothelial ca...