Chonnam National University Hospital

ALKBH10B mediated epitranscriptomic regulation enhances drought tolerance of Arabidopsis thaliana via hormonal cross-talk and sustained photosynthesis

Abstract Key message The m⁶A demethylase ALKBH10B emerges as a crucial post-transcriptional regulator of hormonal crosstalk, photosynthetic maintenance, and mitochondrial energy metabolism to fine-tune plant stress adaptation to drought . Abstract Epitranscriptomic N⁶-methyladeno...

Altered Complement and Tubular Mitochondrial Proteins Are Linked to Graft Loss in DSA+ Antibody–Mediated Rejection

Background: Antibody-mediated rejection (AMR) is the main driver of late kidney allograft loss. Anti-HLA donor-specific antibodies (DSA) are strongly associated with AMR. However, 30-60% of DSA + patients do not develop AMR, raising the possibility of local tissue adaptations to...

TrivalentAl Insertion into Layered-Oxide-DerivedPerovskite Oxynitrides for Defect-Controlled Dielectric Response

Abstract Al-containing perovskite oxynitrides, SrAl0.2M0.8O2.4N0.6 (M = Nb, Ta), were synthesized by ammonolysis of layered Sr5M4O15 precursors with α-Al2O3. This reaction demonstrates that the cation-insertion chemistry of layered-perovskite-derived oxynitrides can be extended t...

Clinical Characteristics and Outcomes of Pediatric Patients With Long QT Syndrome: A Korean Multicenter Cohort Study

This multicenter nationwide cohort study comprehensively analyzed the clinical features, genetic architecture, and outcomes of Korean pediatric patients with long QT syndrome (LQTS).Prolonged QT intervals, fetal arrhythmia, and LQT2/3 genotypes compared to LQT1 were independent r...

Systematic review on the association between brain-related measures and upper limb movement characteristics after stroke

Abstract Background Upper limb (UL) movements are highly diverse, as are movement deficits following stroke. The relationship that stroke pathology has with UL impairments and their recovery has been studied with an increasingly complex array of neuroimaging and neurophysiology t...

Machine learning-assisted prediction of 5-year mortality in chronic kidney disease: the KoreaN cohort study for Outcome in patients With Chronic Kidney Disease (KNOW-CKD)

Background: Mortality prediction models for patients with non-dialysis chronic kidney disease (CKD) remain limited despite their clinical importance. While machine learning (ML) offers the potential to improve prediction accuracy, its "black-box" nature has hindered clinical adop...

Doxorubicin-Incorporated Nanoparticles Composed of Ce6-Conjugated Hyaluronic Acid-b-poly(ethylene glycol) Copolymer for Overcoming Doxorubicin Resistance of Breast Cancer Cells

Oxidative stress in the tumor microenvironment, which is its own intrinsic property, is frequently utilized to deal with the drug-targeting issue in the nanoparticle drug delivery system. For this purpose, reactive oxygen species (ROS)-sensitive nanoparticles encapsulating doxoru...

Blood viscosity is associated with smoking status rather than the presence of chronic obstructive pulmonary disease: findings from the Korea COPD Subgroup Study (KOCOSS)

Abstract Background The relationship between smoking and blood viscosity is well established. However, the role of blood viscosity in the development of chronic obstructive pulmonary disease (COPD) and its impact on lung function decline remains unclear. Therefore, we aimed to in...

Natural history of solitary osteochondroma

Aims: The aim of this study was to analyze the natural history of solitary osteochondroma and determine how skeletal maturity influences tumour behaviour and treatment outcomes. Methods: A retrospective analysis of 236 patients with solitary osteochondroma (151 skeletally immatur...

Development and pilot evaluation of an AI-based pediatric medication safety virtual simulation program for nursing students: a quasi-experimental study in South Korea

PURPOSE: This study aimed to develop an artificial intelligence (AI)-based pediatric medication safety competence (PMSC) virtual simulation program and evaluate its effectiveness among nursing students. METHODS: This quasi-experimental study used a nonequivalent control group pre...